Tsang et al., Cancer Chemother Pharmacol 2003
(Osteosarcoma) :
The results suggested that p53-R175H might induce MRP1 expression and DOX resistance in cells
Tazzari et al., Leukemia 2007
(Acute Disease...) :
Taken together, these data suggest that PI3K/Akt activation may lead to the development of chemoresistance in AML blasts through a mechanism involving a p53 dependent suppression of MRP1 expression
Cui et al., Cell 2007
(Carcinoma, Basal Cell...) :
Here we provide biochemical and genetic evidence demonstrating that UV induction of POMC/MSH in skin is directly controlled by p53 Jiang et al., Zhonghua Yi Xue Za Zhi 2011
:
RAD001 inhibited the p53 dependent expression of MRP1 via an inhibition of phosphoinositide 3-kinase (PI3K)/Akt/mTOR signaling pathway