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DDX58 — TP53
Text-mined interactions from Literome
Hsu et al., FEBS Lett 2012
:
Transfection studies revealed that the
RIG1 promoter activity was greatly
enhanced by wild type but not mutated
p53 protein
Sun et al., Biochim Biophys Acta 2013
(Breast Neoplasms) :
Thus,
DDX3 associates with p53,
increases p53 accumulation, and positively regulates camptothecin induced apoptotic signaling in cells expressing functional wild-type p53, whereas in cells expressing mutant or non-functional p53 DDX3 inhibits activation of the extrinsic apoptotic pathway to reduce caspase activation