Montpetit et al., Nature 2011
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Local activation of Dbp5 at the NPC by Gle1 is essential for mRNA export in vivo ; however, the mechanistic role of Dbp5 in mRNP export is poorly understood and it is not known how Gle1 ( InsP6 ) and Nup159 regulate the activity of Dbp5 Folkmann et al., Nucleus (Austin, Tex.) 2011
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These include a more detailed explanation of the mechanism of Dbp5 RNP remodeling, the role of Gle1-IP6 in stimulating Dbp5 ATPase activity, and the identification of a novel paradigm for regulation of Dbp5 by Nup159 Tieg et al., Biochim Biophys Acta 2013
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For the regulation of its RNA dependent ATPase activity during late steps of nuclear transport, Dbp5 requires the nucleoporin Nup159 and its cofactors Gle1 and IP6