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NOS2 — PI3

Text-mined interactions from Literome

Pahan et al., J Biol Chem 1999 : Taken together, the results from specific chemical inhibitors and dominant negative mutant expression studies demonstrate that apart from the activation of NF-kappaB, inhibition of PI 3-kinase is also necessary for the expression of iNOS and production of NO
Kaliman et al., J Biol Chem 1999 : Regarding the mechanisms involved in IGF-II activation of NF-kappaB, PI 3-kinase inhibition prevented NF-kappaB activation, iNOS expression, and NO production
Liu et al., Circulation 2003 (MAP Kinase Signaling System) : In endothelial cells, aldosterone caused a phosphatidylinositol 3-kinase (PI3K) dependent increase in nitric oxide synthase activity as well as PI3K dependent activation of extracellular signal regulated kinase 1/2 and p70 S6 kinase
Kao et al., Immunology 2005 : In this study, we further investigated the roles of tyrosine kinase, phosphatidylinositiol 3-kinase (PI3K)/Akt , and p38 mitogen activated protein kinase ( MAPK ) in LTA induced iNOS expression and NO release in RAW 264.7 macrophages ... Tyrosine kinase inhibitors ( genistein and tyrphostin AG126 ), PI3K inhibitors ( wortmannin and LY 294002 ), and a p38 MAPK inhibitor ( SB 203580 ) attenuated LTA induced iNOS expression and NO release in concentration dependent manners
Smart et al., Cardiovasc Res 2006 (Myocardial Reperfusion Injury) : IL-6 pre-treatment also resulted in activation of the phosphatidylinositol (PI) 3-kinase/Akt pathway, and both iNOS induction and IL-6 dependent protection were blocked by the PI 3-kinase inhibitor wortmannin
Kasina et al., Nitric Oxide 2006 : A decrease in the level of nitroprofilin in PDBu treated platelets in the presence of inducible nitric oxide synthase inhibitor, 1400W, was observed suggesting that profilin nitration is mediated by PI 3-kinase dependent activation of inducible nitric oxide synthase
Downey et al., Ann N Y Acad Sci 2008 (Myocardial Ischemia) : PI3-kinase causes extracellular signal regulated kinase ( ERK ) -dependent activation of endothelial nitric oxide synthase
Lin et al., Int Immunopharmacol 2010 : On the other hand, PGN induced iNOS and COX-2 up-regulation were attenuated by PI3-kinase inhibitors ( LY294002 and wortmannin ), and an AKT inhibitor
Wang et al., J Cell Physiol 2011 : Taken together, these results suggested that in astrocytes, activation of NF-?B by ET ( B ) -dependent c-Src, PI3K/Akt , and p42/p44 MAPK signalings is necessary for ET-1 induced iNOS gene up-regulation
Liu et al., Eur J Pharmacol 2013 : Furthermore, a phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 significantly suppressed LPS induced NF-?B p65 nuclear translocation, iNOS expression, and NO production, which was also mimicked by pretreatment with DSC
Huang et al., Toxicol Appl Pharmacol 2013 (Inflammation) : We also found that LTA induced iNOS and COX-2 up-regulation were attenuated by p38, JNK, and PI3-kinase inhibitors