Stuhlmeier et al., J Biol Chem 2005
:
Here we probe the involvement of the transcription factor NF-kappaB in induced and noninduced HAS activation
Kao et al., Exp Gerontol 2006
(Arthritis, Rheumatoid) :
The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1
Stuhlmeier et al., J Biol Chem 2008
(MAP Kinase Signaling System...) :
Analyses of virus induced signal cascades, utilizing chemical inhibitors of MAPK and overexpressing mutated IKK and IkappaB, revealed that the MAPK p38 as well as the transcription factor NF-kappaB are essential for virus induced activation of HAS1