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CAPN6 — NFKB1
Text-mined interactions from Literome
Kim et al., Parasitol Res 2001
(Toxoplasmosis) :
An inhibitor of
NF-kappaB activation,
calpain-1 inhibitor , blocked the chemokine secretion induced by live T. gondii
Schölzke et al., Eur J Neurosci 2003
:
Our data indicate that the Ca2+ dependent protease
calpain is
involved in the
NF-kappaB activation in neurons in response to N-methyl-d-aspartate receptor occupancy by glutamate ...
NF-kappaB activation by
calpain may mediate the long-term effects of glutamate on neuron survival or memory formation
Clark et al., Exp Cell Res 2004
(Leukemia, Promyelocytic, Acute) :
This maturation response involves protein kinase C ( PKC ) signaling,
activation of the transcription factor
nuclear factor kappaB (NFkB) , and intracellular calcium and
calpain activity
Yang et al., Chem Res Toxicol 2007
(Necrosis) :
It reduces mitochondrial membrane potential by activating
calpain and
inhibits NF-kappaB activity by increasing the ROS level
Wei et al., Am J Physiol Cell Physiol 2009
:
Altogether, the data demonstrate a signaling pathway by which titanium particles induce oxidative stress, stimulate
calpain mediated
NF-kappaB activation, and activate target gene expression, including COX-2
Chen et al., Arch Biochem Biophys 1997
:
This suggests that
calpain contributes to silica induced I kappa B alpha degradation and
NF-kappa B activation but not to LPS induced I kappa B alpha degradation and NF-kappa B activation