Matsuda et al., Eur J Oral Sci 2002
(MAP Kinase Signaling System) :
The EMD induction of DNA synthesis and activation of ERK 1/2 were diminished by pretreatment with suramin, an inhibitor of receptor tyrosine kinases ( RTK )
Itoh et al., J Periodontal Res 2006
:
Our results indicate that EMD induces the formation of osteoclasts through interaction with RANKL, while ERK and p38 MAPK may play a critical role in the enhancement of osteoclast formation in RAW 264.7 cells
Kémoun et al., Cell Tissue Res 2007
:
Phosphorylation of Smad-1 and MAPK is stimulated by EMD or rhBMP-2
Sakoda et al., Eur J Oral Sci 2012
:
Our results suggest that EMD stimulates VEGF production partially via TGF-ß1 and FGF-2 in human gingival fibroblasts and that EMD induced VEGF production is regulated by ERK, p38 MAPK , and PI3K/Akt pathways