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KRAS — RHOA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Dreissigacker et al., Cell Signal 2006
(Neoplasm Invasiveness...) :
Stable expression of
EGFP-K-Ras ( V12 )
down-regulated the activity of Rac1 and
RhoA , resulting in reduced subcortical actin filaments and stress fibers, which might contribute to the epithelial dedifferentiation
Basu Roy et al., Int J Cancer 2013
(Cell Transformation, Neoplastic...) :
This increased migration is highly dependent on the RhoA GTPase, indicating that an activated
K-RAS modulates migration in part via caveolin-1 induction, and
increasing RhoA activity via phospho-caveolin-1