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IRF6 — NOX4

Text-mined interactions from Literome

Brandes et al., Hypertension 1999 (Endotoxemia...) : Expression of XO and NAD ( P ) H oxidase ( p22phox, p67phox, and gp91phox ) were increased by LPS in a time dependent manner, as were protein tyrosine nitration and ONOO- formation
Melgert et al., J Hepatol 2000 (Inflammation) : Both coupled and uncoupled Dexa showed effective inhibition of LPS induced NOx and TNFalpha production in precision-cut liver slices
Maekawa et al., Inflamm Res 2000 (Liver Neoplasms, Experimental) : Moreover, LPS- or IL-2-stimulation increased the levels of TNF-alpha and NOx in the supernatants of AH-130 cell and macrophage co-culture, although LPS and IL-2 did not induce TNF-alpha and NOx production by AH-130 cells incubated without macrophages
Wang et al., Chin Med J (Engl) 1999 (Intussusception) : Furthermore, LPS increased total NOS activity, NOx production and cGMP levels in plasma or in colic smooth muscle tissues
Piganelli et al., Diabetes 2002 (Diabetes Mellitus, Experimental...) : In addition, pretreatment of lipopolysaccharide (LPS) stimulated peritoneal macrophages with SOD mimic inhibited the LPS dependent increase in TNF-alpha as well as the NADPH oxidase dependent release of superoxide
Mailman et al., Dig Dis Sci 2002 : At 50 microM, luminal NOLARG attenuated the LPS induced NOx secretion and increased blood pressure ... The LPS induced luminal NOx secretion was blocked by 500 microM intraluminal AMGU and NOLARG ... Luminal 500 microM NOLARG prevented the LPS induced increase in plasma [ NOx ] and the decrease in leukocytes, but AMGU did not
Romeo et al., J Pediatr Surg 2003 : LPS stimulation produced a strong increase in NOx production in laparotomy MPhis and control MPhis
Gao et al., J Neurosci 2003 (Nerve Degeneration...) : Second, rotenone and LPS synergistically stimulated the NADPH oxidase mediated release of the superoxide free radical
Gao et al., FASEB J 2003 (Nerve Degeneration...) : Mechanistically, microglial NADPH oxidase mediated generation of reactive oxygen species played a pivotal role in the synergistic neurotoxicity : MPTP and LPS synergistically stimulated the NADPH oxidase mediated release of superoxide free radical ; pharmacological inhibition and genetic inactivation of NADPH oxidase prevented superoxide production and the synergistic neurotoxicity
Tatsumi et al., J Appl Physiol 2004 (Ventricular Dysfunction, Left) : Aminoguanidine, an inhibitor of iNOS, significantly attenuated the LPS induced NOx production and contractile dysfunction
Thakur et al., J Leukoc Biol 2006 : These results demonstrate that chronic ethanol feeding increases LPS stimulated NADPH oxidase dependent production of ROS in Kupffer cells
Rozenberg et al., Crit Care 2006 (Cardiomyopathies) : Myocardial NOx and NO2 were increased in a similar fashion by LPS in young ( both LPS doses ) and senescent rats
Nakahira et al., J Exp Med 2006 : CO attenuated LPS induced NADPH oxidase activity in vitro, potentially by binding to gp91(phox)
Miletic et al., Blood 2007 (Granulomatous Disease, Chronic...) : Here, we identify the Vav family of Rho guanine nucleotide exchange factors ( GEFs ) as critical mediators of LPS induced MyD88 dependent activation of Rac2, NADPH oxidase , and ROI production using mice deficient in Vav1, Vav2, and Vav3
Pacquelet et al., Biochem J 2007 : IRAK-4 phosphorylated p47phox activated the NADPH oxidase in a cell-free system, and IRAK-4 overexpression increased NADPH oxidase activity in response to LPS
Lin et al., J Agric Food Chem 2007 : LPS increased the expression of TLR4 in HASMCs, and this effect was mediated by the activation of nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase , phosphorylation of intracellular mitogen activated protein kinases ( MAPKs ), and increases in the cytoplasmic level of HuR and TLR4 mRNA stability ... G. biloba extract inhibited LPS induced HASMC proliferation and decreased the expression of TLR4 by inhibiting LPS induced NADPH oxidase activation, mRNA stabilization, and MAPK signaling pathways
Deng et al., Zhonghua Xin Xue Guan Bing Za Zhi 2007 : NOx production by 10 ( -7 ) mol/L and 10 ( -6 ) mol/L ALD increased by 50.0 % and 58.7 % respectively ( P < 0.01 ) and iNOS activity was also significantly increased ( P < 0.01 ) in ALD + RU486 group than that in ALD group. ( 2 ) LPS significantly increased the NOx production and iNOS activity ( P < 0.01 ) and these effects were not augmented by adding ALD to LPS ( P > 0.05 ) and SP significantly blocked and RU486 significantly enhanced the effects by LSP and ALD on NOx production and iNOS activity ( P < 0.05 )
Kao et al., J Cardiovasc Pharmacol 2007 (Hypotension...) : In anesthetized rats, LPS caused systemic hypotension and increased biochemical factors, nitrate/nitrite ( NOx ), methyl guanidine ( MG ), tumor necrosis factoralpha (TNFalpha), and interleukin-1beta (IL-1beta)
Oh et al., Neurosci Lett 2008 (Anoxia) : Taken together, these results suggest that LPS induces HIF-1alpha mRNA expression and activation via NADPH oxidase and Sp1 in BV2 microglia
Yoo et al., Neurochem Int 2008 (Encephalitis...) : It also suppressed LPS+IFN-gamma induced NADPH oxidase activation and eventually, the inducible form of superoxide production
Qian et al., J Immunol 2008 (Inflammation) : Moreover, we demonstrate that TGF-beta1 inhibited LPS induced NADPH oxidase ( PHOX ) subunit p47phox translocation from the cytosol to the membrane in microglia within 10 min. Mechanistic studies show that TGF-beta1 fails to protect dopaminergic neurons in cultures from PHOX knockout mice, and significantly reduced LPS induced translocation of the PHOX cytosolic subunit p47phox to the cell membrane
Li et al., Arterioscler Thromb Vasc Biol 2009 (Atherosclerosis) : Furthermore, neither LPS nor DFO affected mRNA and protein levels of p47phox a nonheme containing, regulatory subunit of NADPH oxidase, or the mRNA level of NOX4 , an isoform of the principal catalytic subunit of NADPH oxidase in endothelial cells
Robinson et al., Free Radic Biol Med 2010 : Production of NO metabolites ( NOx ) and OPPC activity by RAW 264.7 cells was significantly increased by stimulation with lipopolysaccharide (LPS) and interferon gamma (IFNgamma) at pO ( 2 ) ranging from 0.07 to 50 %
Kim et al., Immunol Cell Biol 2010 : LPS caused ROS production in macrophages and increased the mRNA expression of Nox isoforms Nox1 and Nox2 by 20-fold and two-fold, respectively
Check et al., Mol Immunol 2010 : Src kinase participates in LPS induced activation of NADPH oxidase ... In mouse macrophage RAW264.7 cells, inhibition of src tyrosine family kinases inhibited LPS induced activation of NADPH oxidase , phosphorylation of p47(phox), activation of PI3K and phosphorylation of the TLR4 ... These data suggest that both src kinase and PI3 kinase are involved in LPS induced NADPH oxidase activation
Zhang et al., Int Immunopharmacol 2010 (Inflammation) : Both DMC and Cur could markedly decrease iROS production and the expression of NADPH oxidase induced by LPS , with more potent inhibitory activity of DMC
Lin et al., Br J Pharmacol 2011 : In addition, LPS stimulated NADPH oxidase activation and ROS generation were attenuated by the NADPH oxidase inhibitors diphenyleneiodonium chloride ( DPI ) and apocynin (APO)
Wagner et al., Alcohol Clin Exp Res 2012 : Alcohol- and LPS induced increases in lung eNOS, Nox1, and Nox4 expression were attenuated by rosiglitazone
Tokuda et al., Antioxid Redox Signal 2012 (Inflammation) : H ( 2 ) S breathing attenuated LPS induced increase of plasma ALT activity and NOx levels and lung MPO activity
Lee et al., Cell communication and signaling : CCS 2012 : LPS induced NADPH oxidase activation, ROS production, and p47phox translocation from the cytosol to the membrane, which were reduced by PP1 or c-Src siRNA
Tracey et al., J Pharmacol Exp Ther 1995 : The ED50 values ( dose that elicited a 50 % inhibition of the LPS dependent increase in [ NOx ] 6 hr after LPS administration ) for L-NG-monomethylarginine acetate, L-NG-nitroarginine methyl ester and aminoguanidine ( administered 3 hr after LPS ) were 34, 21 and 19 mg/kg in the rat and 32, 5 and 4 mg/kg in the mouse