◀ Back to IRF6
IRF6 — MAPKAPK2
Text-mined interactions from Literome
Paul et al., Cell Signal 1999
:
In parallel,
LPS also
stimulated the activation of p38 MAP kinase and the
MAPKAP kinase-2 , a downstream target of p38 MAP kinase ... SB 203580, a specific inhibitor of p38 MAP kinase prevented the
activation of p38 MAP kinase ( IC50 = 3.3 +/- 1.4 microM, n = 3 ) and
MAPKAP kinase-2 by
LPS and reduced the induction of COX-2 by approximately 50-90 %, with no significant effect upon iNOS expression
Thuraisingam et al., Mol Immunol 2007
:
Using a GFP reporter construct under the control of the 3 ' untranslated region of the TNF gene, we demonstrate that S28463 and CpG DNA induced MK2 signalling regulates TNF mRNA primarily at the translational level, whereas
LPS induced
MK2 signalling regulates both the stability and translational efficiency of TNF mRNA
Wan et al., J Biol Chem 2009
(MAP Kinase Signaling System) :
Moreover,
LPS stimulation
induced an interaction of IRAK2 with TRAF6, MKK3/6, and
MK2 , implicating a critical role for mitogen activated protein kinase signaling in LPS induced IRAK2 mediated post-transcriptional control
Wang et al., J Innate Immun 2011
:
Also consistent with a role for TRAM in TNF-a translation,
LPS induced activation of
MK2 , a kinase involved in this process, was impaired in TRAM-deficient BMDM
O'Dea et al., Am J Physiol Lung Cell Mol Physiol 2011
(Acute Lung Injury...) :
LPS induced
p38/MK2 phosphorylation was higher in lung marginated Gr-1 ( high ) than Gr-1 ( low ) monocytes and neutrophils, mirroring TNF expression
Herberich et al., Bioorg Med Chem Lett 2012
:
Further investigation led to the identification of three compounds, 3g, 3j and 3m that are highly potent inhibitors of
LPS induced
MAPKAP kinase 2 (MK2) phosphorylation in 50 % human whole blood ( hWB ), and possess desirable in vivo pharmacokinetic and kinase selectivity profiles
Olajide et al., Evidence-based complementary and alternative medicine : eCAM 2013
:
Results also show that cryptolepine inhibited
LPS induced p38 and
MAPKAPK2 phosphorylation in the microglia
Sanghera et al., J Immunol 1996
:
Consistent with p38 HOG1 mediating
LPS activation of
MAPKAPK2 , treatment with LPS, but not PMA, increased the tyrosine phosphorylation of p38 HOG1, a modification known to elevate the enzymatic capacity of this kinase