◀ Back to IL12RB1
IL12RB1 — IL18
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Yang et al., Nat Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Rodriguez-Galán et al., J Immunol 2005
Evidence: assay, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(transcription, activates)
Parham et al., J Immunol 2002
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Schindler et al., J Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Yang et al., Nat Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
Text-mined interactions from Literome
Okazawa et al., Am J Gastroenterol 2002
(Crohn Disease...) :
The functional activity of IL- 12 and IL-18 was assessed by the
effect of recombinant IL-12 and recombinant
IL-18 on interferon-gamma production, the proliferative response, and the induction of IL-2R,
IL-12R , and IL-18R of LPLs
Frisancho-Kiss et al., Brain Res 2006
(Coxsackievirus Infections...) :
We have previously reported that
IL-12Rbeta1 signaling
increases CVB3 induced myocarditis and
IL-1beta/IL-18 levels in males, while IL-12 ( p35 ) /STAT4 induced IFN-gamma does not alter the severity of acute disease
Hyodo et al., J Immunol 1999
:
These data suggested that NK cells develop and express
IL-12R and IL-18R in the absence of IL-12 or IL-18, and that both
IL-18 and IL-12 directly and independently
augment perforin mediated cytotoxic activity of NK cells