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IFNG — STAT5B
Text-mined interactions from Literome
Storz et al., FEBS Lett 1999
(Rhabdomyosarcoma) :
By contrast, in the same cells,
IFNgamma induced
STAT5b activation was JAK2 dependent, indicating that this signal pathway is functional in Kym-1 cells
Hwa et al., J Biol Chem 2004
:
In summary, our results provide evidence of the following in human primary dermal fibroblasts : ( a ).
IFN-gamma preferentially
activates STAT-5b , but, in the absence of a functional STAT-5b, STAT-5a is activated ; ( b ). IFN-gamma time-dependently up-regulates IGF-I mRNA expression ; ( c ). the regulation of IGF-I requires an active STAT-5b, and activated STAT-5a can not substitute for an inactive STAT-5b ; and ( d ). STAT-5b has an essential role in the transcriptional up-regulation of IGF-I