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CTSS — IFNG

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CTSS → IFNG (increases)
  Evidence: Cathepsin S (CTSS) is induced by IFNG in several cell types including smooth muscle cells. Overexpression of IFNG in mice induces emphysema with increased expression of cathepsins B, D, H, L and S.
• OpenBEL Selventa BEL large corpus: CTSS → IFNG (increases, IFNG Translocation)
  Evidence: Primary cultured human saphenous vein ECs had negligible levels of Cat S mRNA. Exposure to IFNG, IL-1A, or TNF-A caused accumulation of Cat S transcript. However, the angiogenic factors VEGF and bFGF had limited effects on Cat S transcription (Figure 1A). For detection of Cat S protein in ECs, [125I]JPM ethyl ester, the cell-permeable active site probe for cysteine proteases, was used (Figures 1B and 1C). This irreversible probe labels Cat S immediately on activation and does not affect Cat S im...

Text-mined interactions from Literome

Gresser et al., Eur J Immunol 2001 : We show that IFN-gamma stimulated microglia possess active cathepsin L and cathepsin S , and efficiently degrade the invariant chain, unlike IFN-gamma stimulated astrocytes that express cathepsin L but not cathepsin S
Gallardo et al., J Neuropathol Exp Neurol 2001 (Dermatomyositis) : In view of these results, the increased expression of cathepsins L and B after IFN-gamma stimulation in muscle cultures and its inhibition using fludarabine, a STAT1 blocker, further support our previous studies and suggest that the increased expression of cathepsins detected in perifascicular muscle fibers in DM is mediated by IFN-gamma/STAT1 and contributes to their atrophy
Schwarz et al., J Invest Dermatol 2002 (Psoriasis) : Interferon-gamma stimulation of primary keratinocytes and HaCaT cells resulted in a selective upregulation of the cathepsin S activity, the extent of which was very similar
Pang et al., Biochem Biophys Res Commun 2005 : IFN-gamma stimulates both CTSL and CTSS expression after 3 days, but fails to significantly alter CTSK expression
Sendide et al., J Immunol 2005 (Tuberculosis) : This phenotype was due to inhibition of IFN-gamma induced cathepsin S (Cat S) expression in infected cells and the subsequent intracellular accumulation of alphabeta class II dimers associated with the Cat S substrate Ii p10 fragment
Maubach et al., Biochim Biophys Acta 2007 : Importantly, IFN-gamma increases cathepsin S activity, suggesting a possible involvement of this protease in CD74 processing
Geraghty et al., J Biol Chem 2007 (Pulmonary Disease, Chronic Obstructive) : Secretory leucocyte protease inhibitor inhibits interferon-gamma induced cathepsin S expression ... Interferon-gamma is a potent inducer of various cathepsins and matrix metalloproteases ... We have demonstrated that secretory leukocyte protease inhibitor can inhibit interferon-gamma induced cathepsin S production by macrophages
Chan et al., J Leukoc Biol 2010 : We showed that the expression of cathepsin S and MHC-II, inducible by IFN-gamma , was down-regulated in the presence of IL-10 ... Following STAT3 suppression with specific siRNA, the expression of IFN-gamma induced surface MHC-II antigens and cathepsin S levels was restored, even in the presence of IL-10