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FOXO1 — MSTN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MSTN → FOXO1 (directlyIncreases, MSTN Activity) Allen et al., Am J Physiol Cell Physiol 2007*
  Evidence: Moreover, expression of a constitutively active form of FoxO1 increased myostatin mRNA

Text-mined interactions from Literome

Allen et al., Am J Physiol Cell Physiol 2007 : Here we examined the role of FoxO1 and SMAD transcription factors in regulating myostatin gene expression and myoblast differentiation in C ( 2 ) C ( 12 ) myotubes in vitro ... Together these data demonstrate that FoxO1 and SMAD transcription factors regulate the expression of myostatin and contribute to the control of muscle cell growth and differentiation
McFarlane et al., Curr Opin Clin Nutr Metab Care 2008 (Cachexia...) : Molecular analyses reveal that excess levels of myostatin induce Atrogin-1 expression by reducing Akt phosphorylation and thereby increasing FoxO1 activity