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EPHB2 — KDR

Text-mined interactions from Literome

Kim et al., J Biol Chem 2002 : Endostatin blocked VEGF induced tyrosine phosphorylation of KDR/Flk-1 and activation of ERK , p38 MAPK, and p125(FAK) in human umbilical vein endothelial cells
Labrecque et al., Mol Biol Cell 2003 : Removal of caveolin and VEGFR-2 from caveolae by cholesterol depletion resulted in an increase in both basal and VEGF induced phosphorylation of VEGFR-2, but led to the inhibition of VEGF induced ERK activation and endothelial cell migration, suggesting that localization of VEGFR-2 to these domains is crucial for VEGF mediated signaling
Cho et al., Am J Physiol Heart Circ Physiol 2004 : Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF induced phosphorylation of MEK and ERK
Kuriyama et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System) : Activation and translocation of PKCdelta is necessary for VEGF induced ERK activation through KDR in HEK293T cells ... PKC specific inhibitors and human PKCdelta knock-down using siRNA method showed that PKCdelta played an important role in VEGF-KDR induced ERK activation ... VEGF-KDR stimulation did not induce ERK phosphorylation in human PKCdelta-knockdown HEK293T cells, but co-expression of rat PKCdelta-GFP recovered the ERK phosphorylation ... These results indicate that PKCdelta is involved in VEGF-KDR induced ERK activation via C1B domain
Chen et al., Am J Physiol Heart Circ Physiol 2006 : Our results suggest that VEGF promotes cardiomyocyte differentiation predominantly by ERK mediated Flk-1 activation and, to a lesser extent, by Flt-1 activation
Osada et al., J Gastroenterol Hepatol 2006 (Carcinoma, Hepatocellular...) : Although Flk-1 was phosphorylated in response to VEGF ( > 50 ng/mL ), phosphorylated ERK was not detected at these concentrations
Barbarroja et al., Leukemia & lymphoma 2007 (Acute Disease...) : In vitro MEK/ERK and NFkappaB binding activity blockade suppressed the constitutive expression of TF, VEGF, and KDR
Ling et al., Biochem Biophys Res Commun 2007 (Carcinoma, Lewis Lung) : Endostar suppressed the VEGF induced tyrosine phosphorylation of KDR/Flk-1 ( VEGFR-2 ) as well as the overall VEGFR-2 expression and the activation of ERK , p38 MAPK, and AKT in HUVECs
Spirli et al., Gastroenterology 2010 (Cysts...) : In Pkd2-defective LCECs, PKA dependent ERK1/2 signaling controls HIF-1alpha dependent VEGF secretion and VEGFR-2 signaling
Urbinati et al., Arterioscler Thromb Vasc Biol 2012 : VEGFR2 undergoes phosphorylation and triggers pp60src/ERK ( 1/2 ) activation
Li et al., Exp Cell Res 2012 : VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2 mediated activation of ERK
Song et al., Angiogenesis 2012 (Breast Neoplasms...) : Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2 mediated AKT and ERK1/2 signaling pathways
Ji et al., Cell division 2013 : In agreement with the involvement of ß-ARs and VEGFR-2 in the HemEC response, ß-AR antagonists and the VEGFR-2 inhibitor significantly attenuated isoprenaline induced ERK phosphorylation
Wan et al., Respir Res 2013 (Disease Models, Animal...) : Endostatin treatment decreased MVD by inhibiting the expression of VEGF/VEGFR-2 ( Flk-1 ) and the activation of extracellular signal regulated protein kinase 1/2 ( ERK1/2 )