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CCR7 — EPHB2
Text-mined interactions from Literome
Adachi et al., Biochem Biophys Res Commun 2001
(Calcium Signaling...) :
Induction of
CCR7 expression in thymocytes
requires both
ERK signal and Ca ( 2+ ) signal
Li et al., Blood 2007
(MAP Kinase Signaling System) :
Specific inhibition of
ERK during CB DC maturation
enhanced LPS induced up-regulation of
CCR7 and CXCR4 on CB DCs and their chemotaxis toward CCL19 and CXCL12, to a level similar to that of mature AB DCs
Escribano et al., J Immunol 2009
:
In keeping with its prosurvival role, stimulation of
CCR7 induced phosphorylation/inhibition of GSK3beta, which was mediated by the prosurvival regulator Akt1, but it was
independent of
ERK1/2 , a key regulator of chemotaxis
Xu et al., PloS one 2011
(Carcinoma, Non-Small-Cell Lung...) :
LY294002, a selective inhibitor of PI3K that prevents activation of the downstream Akt, did not weaken the
effect of
CCL21/CCR7 on
P-ERK
Akuthota et al., Am J Respir Cell Mol Biol 2013
:
Finally, primed eosinophils stimulated with CCL19 or CCL21 exhibited increased phosphorylation of
ERK in
response to both
CCR7 ligands