◀ Back to CDH1
CDH1 — DNMT1
Text-mined interactions from Literome
Ghoshal et al., Mol Cell Biol 2005
:
In contrast, the depletion of
Cdh1 with small interfering RNA
increased the basal level of
DNMT1 that blocked 5-aza-CdR induced degradation
Lakshmikuttyamma et al., Oncogene 2010
(Leukemia, Myeloid, Acute) :
In support of this model, we found in acute myeloid leukemia cells with hypermethylated p15INK4B and E-cadherin promoters that the
DNMT inhibitor, 5-aza-2'-deoxycytidine,
induced p15INK4B and
E-cadherin expression, and decreased levels of DNA methylation, histone H3 lysine 9 ( H3K9 ) methylation and SUV39H1 associated with p15INK4B and E-cadherin promoters
Espada et al., Nucleic Acids Res 2011
:
Present evidence suggests that the
DNMT1 acts on
E-cadherin expression through its direct interaction with the E-cadherin transcriptional repressor SNAIL1
Peng et al., Mol Cell Biol 2011
:
Finally, inhibition of SIRT1 strengthens the silencing
effects of
DNMT1 on the expression of tumor suppressor genes ER-a and
CDH1 in MDA-MB-231 breast cancer cells
Yi et al., Chemotherapy 2012
(Carcinoma...) :
DNMT inhibitors and HDAC inhibitors
regulate E-cadherin and Bcl-2 expression in endometrial carcinoma in vitro and in vivo