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CDH1 — DDR1
Text-mined interactions from Literome
Eswaramoorthy et al., J Cell Physiol 2010
:
DDR1 regulates the stabilization of cell surface
E-cadherin and E-cadherin mediated cell aggregation ... Previously, we reported that discoidin domain receptor 1 (DDR1) forms a complex with E-cadherin at adhesive contacts ; however, the regulatory
role of
DDR1 in the stabilization of cell surface
E-cadherin and E-cadherin mediated cell behaviors remained undefined ... We performed Western blotting, immunofluorescence analysis, flow cytometry, and cell aggregation studies to investigate the
effect of
DDR1 on cell surface
E-cadherin ... Collagen disrupted the formation of E-cadherin complexes and caused E-cadherin to accumulate in the cytoplasm ; however, over-expression of
DDR1 stabilized
E-cadherin on the cell surface and decreased its cytoplasmic accumulation ... Furthermore, independently of collagen stimulation, the depletion of
DDR1 resulted in a decrease in the level of cell surface
E-cadherin , which consequently caused its cytoplasmic accumulation and decreased E-cadherin mediated cell aggregation ... Furthermore, independently of collagen stimulation, the depletion of
DDR1 resulted in a decrease in the level of cell surface
E-cadherin , which consequently caused its cytoplasmic accumulation and decreased E-cadherin mediated cell aggregation ... These results indicate that
DDR1 can
increase the stability of cell surface
E-cadherin and promote MDCK cell aggregation, which may be mediated through the formation of DDR1/E-cadherin complexes
Yeh et al., Mol Biol Cell 2011
:
Here we show that DDR1 overexpression augmented, whereas dominant negative mutant (
DN-DDR1 ) or knockdown of DDR1
inhibited E-cadherin localized in cell-cell junctions in epithelial cells ... Expression of
DDR1 augmented
E-cadherin protein levels by decreasing its degradation rate ... Photobleaching and photoconversion of E-cadherin conjugated with Eos fluorescence protein demonstrated that
DDR1 increased the stability of
E-cadherin on the cell membrane, whereas sh-DDR1 decreased it ... Pull-down assay and expression of constitutively active or dominant negative Cdc42 showed that
DDR1 stabilized
E-cadherin through inactivation of Cdc42
Miao et al., Med Oncol 2013
:
Enhanced DDR1 expression mediated by collagen I could activate MMP-2, N-cadherin and vimentin expression, but reduce E-cadherin expression ; however, inhibition of
DDR1 expression could suppress MMP-2, N-cadherin and vimentin expression and
induce E-cadherin activation