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BMP2 — TNFSF11
Text-mined interactions from Literome
Koide et al., Biochem Biophys Res Commun 1999
:
It is noted that
BMP-2 alone did
cause an increase in the expression of both COX-2 and
ODF genes ... Since
BMP-2 alone
induced the expression of COX-2 and
ODF genes in osteoblast-like cells, it appears to be one of the regulating factors of osteoclastogenesis
Otsuka et al., Calcif Tissue Int 2003
:
Since the formation of osteoclasts was inhibited dose-dependently by exogenous OPG, the expression of
RANKL in
response to
BMP-2 appeared to be critical for the formation of osteoclasts
Wittrant et al., Int J Oncol 2006
(Bone Neoplasms...) :
RANKL directly
induces bone morphogenetic protein-2 expression in RANK expressing POS-1 osteosarcoma cells ... Results revealed a
RANKL induced increase in ERK phosphorylation, as well as
BMP-2 induction at the mRNA and protein levels, and a decrease of POS-1 cell proliferation in the presence of 10 ng/ml RANKL ... Moreover, a 2-fold molar excess of soluble RANK blocks the
RANKL induced
BMP-2 expression, demonstrating that the biological effects of RANKL observed in POS-1 cells are mediated by RANK
Usui et al., J Bone Miner Res 2008
(Fractures, Bone) :
Murine and chicken chondrocytes regulate osteoclastogenesis by producing
RANKL in
response to
BMP2 ... A reporter assay was used to determine whether
BMP2 induced
RANKL production is through transcriptional regulation of the RANKL promoter and whether it is mediated by Runx2 ... Deletion or mutation of Runx2 binding sites within the RANKL promoter or overexpression of a dominant negative Runx2 abolished
BMP2- and Smad1 mediated
activation of
RANKL promoter activity ... Hypertrophic chondrocytes may regulate osteoclastogenesis at growth plates to remove calcified matrix through
BMP induced
RANKL expression
Fujita et al., Molecular cancer 2007
(Plasmacytoma) :
Attenuation of WNT signaling by DKK-1 and -2 regulates
BMP2 induced osteoblast differentiation and expression of OPG,
RANKL and M-CSF
Susperregui et al., J Cell Physiol 2008
:
Similarly, PTHrP did not significantly modify the
BMP regulated expression of
RANKL or OPG, cytokines involved in osteoclastogenesis
Osako et al., Circ Res 2010
(Calcinosis...) :
RANKL induced the calcification inducer
bone morphogenetic protein-2 by human aortic endothelial cells ( HAECs ) and decreased the calcification inhibitor matrix Gla protein (MGP) in human aortic smooth muscle cells ( HASMCs ), as quantified by real-time PCR and Western blot analysis
Granholm et al., Bone 2013
:
Moreover, the data show that
BMP-2 not only stimulates osteoblastic differentiation but can also
induce osteoclastogenesis through increased
RANKL