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AHR — IL12B
Text-mined interactions from Literome
Kuribayashi et al., Clin Exp Allergy 2002
(Asthma...) :
We investigated whether
IL-12 administered after antigen challenge could
diminish airway hyper-reactivity (AHR) and eosinophilia in mice actively sensitized to ovalbumin ... Mice were analysed for
effects of
IL-12 on
AHR , inflammatory cell infiltration and cytokine levels in lung tissue as well as serum immunoglobulin ( Ig ) E levels ... These data indicate that
IL-12 can
attenuate established antigen induced
AHR and inflammation
Onari et al., Clin Exp Allergy 2009
(Asthma...) :
The results suggest that endogenous
IL-12p40 is
essential for inhibition of
AHR and peribronchial fibrosis, but not eosinophilic inflammation, in a murine asthma model with prolonged antigen exposures