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Li et al., Zhonghua Yi Xue Za Zhi 1998
(Hypoproteinemia...) :
rhGH significantly up-regulated albumin mRNA expression in vitro ( 143 +/- 6 vs 100.4 +/- 2.2, P < 0.01 ) and in vivo ( 152 +/- 8 Vs 100 +/- 3, P < 0.01 ), and obviously alleviated the inhibition of
albumin mRNA expression
induced by
LPS ( P < 0.05 )
Wang et al., Zhonghua Wai Ke Za Zhi 2004
:
To investigate the potential molecular mechanism underlying down-regulation of
albumin expression
induced by
lipopolysaccharide (LPS) in rat hepatocytes ... The results indicate that
LPS can
induce the reduction of
albumin synthesis by down-regulation of albumin mRNA expression at transcription level, and the process may be related to the signal transducation of extracellular signal regulated kinase and p38 kinase
Wang et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2004
:
CHX could block the pathway of
LPS induced down-regulation of expression of
albumin gene at least at the transcription level ... The results suggest that
LPS can indirectly
inhibit the transcription of
albumin gene through cytokines such as IL-6 and TNF-alpha
Wang et al., J Surg Res 2004
:
The present studies were performed to identify whether the reduction of
albumin expression
induced by
LPS was mediated by activating nuclear factor kappa B(NF-kappaB) in cultured rat hepatocytes ... This reduction in
albumin expression
induced by
LPS can be completely inhibited by SN50 in different concentrations, and the maximal increase in albumin was observed at a SN50 dosage of 30 microg/ml ... The results suggest that
LPS inhibits
albumin expression by activating NF-kappaB signaling
Wang et al., Hepatobiliary Pancreat Dis Int 2005
:
LPS can
inhibit albumin synthesis in rat hepatocytes by prevention of albumin transcription
Wang et al., Chin Med J (Engl) 2005
(MAP Kinase Signaling System) :
The present study was designed to identify if the reduction of
albumin expression is directly
induced by
LPS and modulated by activated extracellular signal regulated protein kinase ( ERK ) and p38 mitogen activated protein kinase ( MAPK ) in rat hepatocytes ... The ERK inhibitor PD98059 caused a significant increase in
LPS induced
albumin production at the three concentrations ( 119.7, 111.4 and 80.0 ng/ml vs 44.4 ng/ml, P=0.0013, 0.0025 and 0.009, respectively ), whereas SB203580 obviously blocked albumin reduction in LPS treated cells at the concentrations of 10 and 50 micromol/L ( 87.5 and 93.6 ng/ml vs 44.4 ng/ml, P=0.0076 and 0.0049, respectively ) ...
LPS can
induce the reduction of
albumin expression by new synthesized proteins indirectly, and the process may be related to the signal proteins of ERK and p38 kinase
Borrelli et al., Clinical and vaccine immunology : CVI 2008
:
The binding of anti-peptide polyclonal antibodies to
LPS could be
inhibited by LPS, PS, MDWNMHAA, and MDWNMHAA-bovine serum
albumin , as assessed by inhibition enzyme linked immunosorbent assay
Uchiba et al., Am J Physiol 1996
:
The intravenous administration of AT III prevented the pulmonary accumulation of leukocytes ( as evaluated by myeloperoxidase activity ) and the increase in pulmonary vascular permeability to 125I-bovine serum
albumin induced by
LPS
Jungi et al., Infect Immun 1997
:
Macrophages were activated by
LPS in the presence of serum or in the
presence of
albumin demonstrated to be free of LBP