Gene interactions and pathways from curated databases and text-mining

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RIPK1 — TNF

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zhang et al., J Biol Chem 2007 (MAP Kinase Signaling System) : Our results demonstrate that RIP1 mediated AIP1 phosphorylation at the 14-3-3 binding site Ser-604 is essential for TNF induced TRAF2-RIP1-AIP1-ASK1 complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling
Vanden Berghe et al., Mol Cell 2007 (Necrosis) : In a recent issue of Molecular Cell, Kim et al. ( 2007 ) reported on a novel TNF receptor 1 necrotic signaling complex inducing TRADD- and RIP1 dependent recruitment and activation of the ROS generating Nox1 NADPH oxidase complex
Varfolomeev et al., J Biol Chem 2008 : Therefore, c-IAP1 and c-IAP2 are required for TNFalpha stimulated RIP1 ubiquitination and NF-kappaB activation
Shembade et al., EMBO J 2009 : RNF11 negatively regulated RIP1 and TRAF6 ubiquitination upon stimulation with TNF and LPS, respectively
Xu et al., J Biol Chem 2010 : Notably, knockdown of USP21 in HeLa cells enhances TNFalpha induced RIP1 ubiquitination, IkappaB kinase beta (IKKbeta), and NF-kappaB phosphorylation, inhibitor of NF-kappaB alpha ( IkappaB alpha ) phosphorylation and ubiquitination, as well as NF-kappaB dependent gene expression
Wong et al., Cell Death Differ 2010 : To determine the role of RIPK1 in TNF/IAP antagonist induced death, we compared wild type ( WT ) and RIPK1 ( -/- ) mouse embryonic fibroblasts ( MEFs ) treated with these compounds
Irrinki et al., Mol Cell Biol 2011 (Necrosis) : FADD was found to mediate formation of the TNF-a induced pronecrotic RIP1-RIP3 kinase complex, whereas the I?B Kinase ( IKK ) subunit NEMO appears to function downstream of RIP1-RIP3
Zhang et al., Neurotox Res 2013 : Although the increased RIP1 activity induced by tumor necrosis factor a activates mitogen activated protein kinases ( MAPKs ) including ERK and leads to apoptotic or necrotic cell death, it is unclear what is the role of ERK during the process of necroptosis
Moujalled et al., Cell death & disease 2013 (Necrosis) : RIPK1 is therefore not essential for TNF to activate RIPK3 to induce necroptosis nor for the formation of a functional ripoptosome/necrosome