Shimamura et al., Cancer Res 2008
(Adenocarcinoma...) :
In contrast, Hsp90 inhibition overcomes these limitations in vitro and depletes cells of EGFR, other RTKs, and phospho-Akt and inhibits mTOR signaling whether or not T790M is present
Delgoffe et al., Mol Immunol 2009
:
Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation ... Pharmacologic inhibition of Hsp90 leads to a decrease in raptor expression and TORC1 activity