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CAPN15 — NOS3
Text-mined interactions from Literome
Su et al., Am J Physiol Lung Cell Mol Physiol 2000
(Anoxia) :
Role of
calpain in hypoxic inhibition of
nitric oxide synthase activity in pulmonary endothelial cells
Stalker et al., FASEB J 2003
:
Immunoprecipitation studies revealed that glucose induces loss of NO via a
calpain dependent decrease in the association of hsp90 with endothelial
nitric oxide synthase
Stalker et al., Diabetes 2005
(Diabetes Mellitus, Type 2) :
Immunoprecipitation studies revealed
calpain dependent loss of association between
eNOS and the regulatory protein heat shock protein 90
Cui et al., Am J Respir Cell Mol Biol 2005
:
Involvement of
calpain-calpastatin in cigarette smoke
induced inhibition of lung endothelial
nitric oxide synthase ... In this study, we evaluated the
role of
calpain-calpastatin in CSE induced decrease in
eNOS gene expression ... To investigate whether CSE induced inhibition of
eNOS gene expression is
caused by decreased
calpain activity due to an increase in calpastatin protein content, we cloned calpastatin gene from PAEC and constructed adenovirus vectors containing calpastatin ... These results indicate that CSE induced inhibition of
eNOS expression in PAEC is
caused by
calpain inhibition due to an increase in calpastatin protein content
Dong et al., J Cell Mol Med 2009
:
Activation of protease
calpain by oxidized and glycated LDL
increases the degradation of endothelial
nitric oxide synthase ... HOG-LDL may impair endothelial function by inducing
calpain mediated
eNOS degradation in a ROS- and Ca ( 2+ ) -dependent manner
Averna et al., J Biol Chem 2008
:
We propose that the protective effect exerted by HSP90 on
eNOS degradation
mediated by
calpain represents a novel and critical mechanism that assures the reversibility of the intracellular trafficking and activation of the synthase
Prangsaengtong et al., Hum Cell 2012
:
Calpain 1 is involved in the degradation of eNOS and Hsp90 and the phosphorylation of eNOS, while
calpain 2
regulates eNOS phosphorylation during cord formation by lymphatic endothelial cells on Matrigel
Brorson et al., Stroke 1995
:
Among various processes that have been thought to mediate the toxic effects of glutamate are activation of the Ca ( 2+ ) -dependent proteases
calpain I and II and the
activation of
nitric oxide synthase