◀ Back to TP53
NEDD8 — TP53
Pathways - manually collected, often from reviews:
-
NCI Pathway Database p53 pathway:
FBXO11 (FBXO11)
→
p53/NEDD8 complex (TP53-NEDD8)
(modification, activates)
Abida et al., J Biol Chem 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database p53 pathway:
p53 (TP53)
→
NEDD8 (NEDD8)
(modification, collaborate)
Abida et al., J Biol Chem 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database p53 pathway:
p53 (TP53)
→
p53/NEDD8 complex (TP53-NEDD8)
(modification, collaborate)
Abida et al., J Biol Chem 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database p53 pathway:
NEDD8 (NEDD8)
→
p53/NEDD8 complex (TP53-NEDD8)
(modification, collaborate)
Abida et al., J Biol Chem 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database p53 pathway:
p53 (TP53)
→
NEDD8 (NEDD8)
(modification, collaborate)
Xirodimas et al., Cell 2004*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database p53 pathway:
p53 (TP53)
→
p53/NEDD8 complex (TP53-NEDD8)
(modification, collaborate)
Xirodimas et al., Cell 2004*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database p53 pathway:
NEDD8 (NEDD8)
→
p53/NEDD8 complex (TP53-NEDD8)
(modification, collaborate)
Xirodimas et al., Cell 2004*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database p53 pathway:
MDM2 (MDM2)
→
p53/NEDD8 complex (TP53-NEDD8)
(modification, activates)
Xirodimas et al., Cell 2004*
Evidence: mutant phenotype, assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
NEDD8
—
TP53
(physical association, affinity chromatography technology)
Loftus et al., EMBO Rep 2012*
-
IRef Biogrid Interaction:
NEDD8
—
TP53
(physical association, affinity chromatography technology)
Leidecker et al., Cell cycle (Georgetown, Tex.) 2012*
-
IRef Biogrid Interaction:
NEDD8
—
TP53
(physical association, affinity chromatography technology)
Xirodimas et al., Cell 2004*
-
IRef Biogrid Interaction:
NEDD8
—
TP53
(physical association, affinity chromatography technology)
Carter et al., Nat Cell Biol 2007*
-
IRef Biogrid Interaction:
NEDD8
—
TP53
(physical association, affinity chromatography technology)
Yang et al., Oncogene 2007*
-
IRef Biogrid Interaction:
NEDD8
—
TP53
(direct interaction, pull down)
Abida et al., J Biol Chem 2007
-
IRef Biogrid Interaction:
NEDD8
—
TP53
(physical association, affinity chromatography technology)
Li et al., Arch Biochem Biophys 2006
-
IRef Biogrid Interaction:
NEDD8
—
TP53
(physical association, affinity chromatography technology)
Liu et al., Oncogene 2010*
-
IRef Biogrid Interaction:
NEDD8
—
TP53
(physical association, affinity chromatography technology)
Wang et al., PloS one 2011*
-
IRef Hprd Interaction:
TP53
—
NEDD8
(in vivo)
Li et al., Arch Biochem Biophys 2006
-
IRef Intact Interaction:
Complex of 50 proteins
(association, anti tag coimmunoprecipitation)
Coffill et al., EMBO Rep 2012
-
IRef Intact Interaction:
Complex of TP53-FBXO11-NEDD8-UBA3-UBE2M-NAE1
(neddylation reaction, enzymatic study)
Abida et al., J Biol Chem 2007
Text-mined interactions from Literome
Liu et al., Oncogene 2010
:
In this study we show that
NEDD8 ultimate buster 1 (NUB1) , a non-covalent interactor of the Ubl NEDD8 ( neural precursor cell expressed, developmentally downregulated 8 ),
controls the localization of
p53
Sun et al., J Biol Chem 2010
:
Knocking down endogenous
NEDD8 suppressed
p53 activation induced by knockdown of L30