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KAT5 — TP53

Pathways - manually collected, often from reviews:

• NCI Pathway Database p53 pathway: TIP60 (KAT5) → p53 (tetramer) complex (TP53) (modification, activates)
  Tang et al., Mol Cell 2006, Sykes et al., Mol Cell 2006, Mellert et al., Cell cycle (Georgetown, Tex.) 2007*
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: KAT5 — TP53 (direct interaction, enzymatic study) Tang et al., Mol Cell 2006
• IRef Biogrid Interaction: KAT5 — TP53 (physical association, affinity chromatography technology) Cheng et al., Oncogene 2008*
• IRef Biogrid Interaction: KAT5 — TP53 (physical association, affinity chromatography technology) Tang et al., Mol Cell 2006
• IRef Biogrid Interaction: KAT5 — TP53 (physical association, affinity chromatography technology) Tyteca et al., EMBO J 2006*
• IRef Biogrid Interaction: KAT5 — TP53 (physical association, affinity chromatography technology) Legube et al., J Biol Chem 2004*
• IRef Biogrid Interaction: KAT5 — TP53 (physical association, affinity chromatography technology) Kurash et al., Mol Cell 2008*
• IRef Hprd Interaction: TP53 — KAT5 (in vivo) Tyteca et al., EMBO J 2006*
• IRef Intact Interaction: KAT5 — TP53 (physical association, anti tag coimmunoprecipitation) Tang et al., Cell 2008

Text-mined interactions from Literome

Legube et al., J Biol Chem 2004 : Moreover, Tip60 is required for p53 to activate the endogenous p21 promoter, suggesting that it functions as a p53 co-activator
Nayak et al., Cell death & disease 2012 : Activation of p53 was mediated by phosphorylation of the histone acetyltransferase Tip60 by glycogen synthase kinase ( GSK ) 3, leading to activation of p53 by acetylation
Zhang et al., International journal of clinical and experimental pathology 2013 (Lung Neoplasms) : Moreover, KAT8 inhibition led to p53 induction and subsequently reduced bcl-2 expression
Dai et al., J Biol Chem 2013 (Cell Transformation, Neoplastic) : Nevertheless, it remains unclear how TIP60 mediated effects on p53 are dynamically regulated in vivo