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PTGS2 — STAT1

Text-mined interactions from Literome

Xuan et al., Circulation 2005 (MAP Kinase Signaling System) : In mice preconditioned with six 4-minute coronary occlusion/4-minute reperfusion cycles, we found that ( 1 ) ischemic PC activates the Raf1-mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase kinase ( MEK) 1/2-p44/42 MAPK signaling pathway, induces phosphorylation of STAT1 and STAT3 on the Ser-727 residue, and upregulates COX-2 expression ; ( 2 ) pSer-STAT1 and pSer-STAT3 form complexes with pTyr-p44/42 MAPKs in preconditioned myocardium, supporting the concept that Ser phosphorylation of these 2 factors is mediated by activated p44/42 MAPKs ; and ( 3 ) activation of the Raf-1-MEK-1/2-p44/42 MAPK-pSer-STAT1/3 pathway and induction of COX-2 during ischemic PC are dependent on protein kinase C (PKC)-epsilon activity, as determined by both pharmacological and genetic inhibition of PKCepsilon
Kim et al., Free Radic Biol Med 2008 : The inhibition of STAT1 and STAT3 by EP prevented their translocation to the nucleus and consequently inhibited expression of iNOS and COX-2 by inhibiting STAT1- and STAT3 mediated transcriptional activity, followed by changes in chromatin conformation via deacetylation of histones H3 and H4 in both gene promoters
Tsoyi et al., Cell Signal 2008 : However, AG490, a specific JAK-2/STAT-1 inhibitor, efficiently prevented LPS mediated iNOS induction but not the induction of COX-2 , and CKD712 completely blocked STAT-1 phosphorylation by LPS, suggesting that the NF-kappaB and JAK-2/STAT-1 pathways but not the JNK pathway are important for CKD712 action
Baitsch et al., Arterioscler Thromb Vasc Biol 2011 (Inflammation) : In addition, M1 macrophage responses ( migration, generation of reactive oxygen species, antibody dependent cell cytotoxicity, phagocytosis ), as well as poly ( I:C ) - or interferon-? induced production of proinflammatory cytokines ; cyclooxygenase-2 expression ; and activation of nuclear factor-?B, I?B, and STAT1 , were suppressed in VLDL-R- or apoER2 expressing cells
Min et al., Int Immunopharmacol 2011 (Inflammation) : Withaferin A down-regulates lipopolysaccharide induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cells ... Taken together, these results suggest that withaferin A inhibits LPS induced PGE ( 2 ) production and COX-2 expression, at least in part, by blocking STAT1 and STAT3 activation