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RELA — SMAD4
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Arsura et al., Oncogene 2003
(Carcinoma, Hepatocellular...) :
Transient activation of
NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1
inhibits AP-1/SMAD signaling and apoptosis : implications in liver tumor formation
Saika et al., Am J Pathol 2005
(Burns, Chemical...) :
Expression of exogenous Smad7 in burned corneal tissue resulted in reduced
activation of
Smad signaling and nuclear factor-kappaB signaling via
RelA/p65
Tzimas et al., Cell Signal 2006
:
Overexpression of USP31 in HEK 293T cells inhibited TNFalpha, CD40, LMP1, TRAF2, TRAF6 and IKKbeta mediated
NF-kappaB activation, but did not
inhibit Smad mediated transcription activation
Eliseev et al., Exp Cell Res 2006
(Bone Neoplasms...) :
Here, we show that in osteosarcoma Saos2 osteoblasts,
NFkappaB regulates the activity of the
BMP/Smad signaling ... We therefore conclude that in osteosarcoma Saos2 cells,
NFkappaB represses
BMP/Smad signaling and BMP2 induced differentiation through Smad7
Grau et al., Cell Signal 2006
(Colonic Neoplasms) :
Role of
Smad proteins in the regulation of
NF-kappaB by TGF-beta in colon cancer cells ...
Smad4 restores the TGF-beta-1 mediated
NF-kappaB activation in SW480 cells ... Taken together, these results suggest a
role for
Smad4 in the transcriptional activation of
NF-kappaB , and a direct effect of Smad 7 inhibiting IkappaB-alpha phosphorylation rather than through the well established inhibition of Smad2/3 phosphorylation with subsequent inhibition of the TGF-beta pathway
Li et al., J Bone Miner Res 2007
(Osteoporosis) :
The
effect of TNFalpha induced
NF-kappaB signaling on
Smad signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators, and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR
Graham et al., Prostate 2009
(Neoplasm Metastasis...) :
PI3K/Akt dependent transcriptional regulation and
activation of
BMP-2-Smad signaling by
NF-kappaB in metastatic prostate cancer cells ... In this study, we investigated whether the nuclear transcription factor
NF-kappaB , implicated in PC metastasis, is
involved in transcriptional regulation and activation of BMP-2 or
BMP-4/Smad signaling in PC cells ... Notably, the activation of BMPRII by BMP-2 is required for modulation of
Smad activation by
NF-kappaB in PC cells