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PTGS1 — RELA
Text-mined interactions from Literome
Rioux et al., Carcinogenesis 2000
:
These data suggest that ROS, generated during pulmonary metabolism of NNK could act as signal transduction messengers and activate
NF-kappaB , which will subsequently
induce COX-1 activity and increase PGE ( 2 ) synthesis
Nanji et al., Am J Physiol Gastrointest Liver Physiol 2001
(Endotoxemia...) :
We analyzed liver histopathology, lipid peroxidation, cytochrome P-450 (CYP)2E1 activity, nonheme iron, endotoxin,
nuclear factor-kappa B (NF-kappa B) activation , and mRNA levels of
cyclooxygenase-1 (COX-1) and COX-2, tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein-1 (MCP-1), and macrophage inflammatory protein-2 ( MIP-2 )
Benito et al., Ann Rheum Dis 2005
(Disease Progression...) :
The inflammatory cell infiltrate, blood vessel formation, and angiogenic factors,
NF-kappaB activation , expression of tumour necrosis factor alpha (TNFalpha) and interleukin 1beta (IL1beta), and the presence of cyclo-oxygenase
(COX)-1 and COX-2 were quantified
Cho et al., American journal of physiology. Renal physiology 2009
(Disease Models, Animal...) :
The untreated CKD rats exhibited azotemia, hypertension, hypertriglyceridemia, proteinuria, glomerulosclerosis, tubulointerstitial damage, upregulation of MCP-1, plasminogen activator inhibitor-1 ( PAI-1 ), transforming growth factor ( TGF ) -beta, cyclooxygenase
(COX)-1 , COX-2, and NAD ( P ) H oxidase ( NOX-4, gp91(phox), p47(phox) and p22(phox) subunits ) and
activation of
NF-kappaB ( IkappaB phosphorylation )
Ivanov et al., Cell Signal 2010
:
The
NF-kappaB dependent gene expression of IL8, IL6,
PTGS2/COX2 , TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 ( PGE2 ) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB dependent gene expression in bystander cells
Hoshino et al., J Med Chem 2010
:
Two metabolites showed activity in these assays ; the 3-sulfate exhibited QR1 induction, DPPH free radical scavenging, and
COX-1 and COX-2 inhibitory activities and the 4'-sulfate
inhibited NFkappaB induction, as well as COX-1 and COX-2 activities
Munroe et al., J Inflamm 1995
:
Overexpression of
PGHS1 strongly
potentiated NF-kappa B activation by phorbol esters and dramatically elevated the generation of intracellular reactive oxygen species ( ROS ) in response to low concentrations of t-butyl peroxide
Lo et al., J Trauma 1998
(Multiple Trauma) :
Inhibition of
NFkappaB with TPCK
reduced COX-2 but not
COX-1 gene expression and decreased PGE2 production by LPS stimulated Mphi
Jobin et al., Immunology 1998
:
Specific
NF-kappaB blockade selectively
inhibits tumour necrosis factor-alpha induced COX-2 but not constitutive
COX-1 gene expression in HT-29 cells