Gene interactions and pathways from curated databases and text-mining

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PIK3CA — RAF1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Sutor et al., J Biol Chem 1999 : Analysis of the upstream pathway leading to MEK activation revealed that inhibition of PI3-K did not block c-Raf activation, whereas MEK activation was effectively blocked under these conditions ... Because c-Raf activation and MEK activation were inversely affected by PI3-K- and cAMP dependent pathways, we examined whether IL-3 activated the alternative Raf isoforms A-Raf and B-Raf
Guillemot et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Taken together, these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region, both in a p21(ras)/Raf-1/MEK/ERK dependent manner, and also involves PI3K and SHP-2
Nakayama et al., Biochem Biophys Res Commun 2003 (MAP Kinase Signaling System) : We also demonstrated that Raf1 is phosphorylated and involved in the production of TNF-alpha and tyrosine phosphorylation of PI3-K via ERK
Krepinsky et al., Cell Signal 2005 : Although phosphatidylinositol-3-kinase (PI3-K) may mediate Raf-1 activation, PI3-K inhibition with wortmannin or LY294002 had no effect on stretch induced Raf-1 activation
Duca et al., Mol Pharmacol 2005 : kappaE induced Raf-1 phosphorylation and activation in a PI3K dependent manner
Carpentier et al., Rev Neurol (Paris) 2005 (Brain Neoplasms...) : High expression of the EGF receptor by tumor cells, activation of the PI3K/Akt and the Ras/Raf pathways represent interesting targets for new selective drugs under development
Romano et al., Endocrinology 2006 : Under the same conditions, PI3K and Akt inhibition also both increased Raf-1 kinase activity and the levels of GTP bound ( active form ) monomeric G protein Rap1, which suggests that a down-regulation of the ERK-1/2 cascade is induced by the PI3K/Akt signaling pathway in unstimulated cells
Le Guilloux et al., Rev Neurol (Paris) 2008 (Brain Neoplasms...) : High expression of the EGF receptor by tumor cells, activation of the PI3K/Akt and the Ras/Raf pathways represent interesting targets for new selective drugs under development
Chang et al., Pharmacol Res 2009 : Moreover, PKC-alpha and PI3K signal might be involved in YC-1 induced Raf-1 activation
Yang et al., Eur J Pharmacol 2010 : These results suggest that plumbagin activates NAD ( P ) H oxidase, Src, and PI3K, and that the activated PI3K or PDK1 subsequently stimulate Akt and Ras-Raf-MEK1/2-ERK1/2 in 3T3-L1 cells
King et al., Mol Cell Biol 1997 : Phosphatidylinositol 3-kinase is required for integrin stimulated AKT and Raf-1/mitogen activated protein kinase pathway activation