Hakak et al., Oncogene 2000
:
Since activation of Akt is dependent on PI3-kinase, this suggests that the effect of Shp-2 on Akt activation may be mediated , at least in part, by its effects on the interaction between PI3-kinase and Cbl
Kwon et al., Endocrinology 2006
:
However, the mechanism by which SHP-2 phosphatase activity or the recruitment of SHP-2 to other signaling molecules contributes to IGF-I stimulated PI-3 kinase activation has not been determined
Ehrhardt et al., J Virol 2007
:
Recently it has been shown by several laboratories that the influenza A virus nonstructural protein 1 (A/NS1) binds and activates phosphatidylinositol 3-kinase (PI3K)