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NOS2 — PI3
Text-mined interactions from Literome
Pahan et al., J Biol Chem 1999
:
Taken together, the results from specific chemical inhibitors and dominant negative mutant expression studies demonstrate that apart from the activation of NF-kappaB, inhibition of
PI 3-kinase is also
necessary for the expression of
iNOS and production of NO
Kaliman et al., J Biol Chem 1999
:
Regarding the mechanisms involved in IGF-II activation of NF-kappaB,
PI 3-kinase inhibition
prevented NF-kappaB activation,
iNOS expression, and NO production
Liu et al., Circulation 2003
(MAP Kinase Signaling System) :
In endothelial cells, aldosterone caused a
phosphatidylinositol 3-kinase (PI3K) dependent increase in
nitric oxide synthase activity as well as PI3K dependent activation of extracellular signal regulated kinase 1/2 and p70 S6 kinase
Kao et al., Immunology 2005
:
In this study, we further investigated the
roles of tyrosine kinase,
phosphatidylinositiol 3-kinase (PI3K)/Akt , and p38 mitogen activated protein kinase ( MAPK ) in LTA induced
iNOS expression and NO release in RAW 264.7 macrophages ... Tyrosine kinase inhibitors ( genistein and tyrphostin AG126 ),
PI3K inhibitors ( wortmannin and LY 294002 ), and a p38 MAPK inhibitor ( SB 203580 )
attenuated LTA induced
iNOS expression and NO release in concentration dependent manners
Smart et al., Cardiovasc Res 2006
(Myocardial Reperfusion Injury) :
IL-6 pre-treatment also resulted in activation of the phosphatidylinositol (PI) 3-kinase/Akt pathway, and both
iNOS induction and IL-6 dependent protection were
blocked by the
PI 3-kinase inhibitor wortmannin
Kasina et al., Nitric Oxide 2006
:
A decrease in the level of nitroprofilin in PDBu treated platelets in the presence of inducible nitric oxide synthase inhibitor, 1400W, was observed suggesting that profilin nitration is mediated by
PI 3-kinase dependent activation of inducible
nitric oxide synthase
Downey et al., Ann N Y Acad Sci 2008
(Myocardial Ischemia) :
PI3-kinase causes extracellular signal regulated kinase ( ERK ) -dependent activation of endothelial
nitric oxide synthase
Lin et al., Int Immunopharmacol 2010
:
On the other hand, PGN induced
iNOS and COX-2 up-regulation were
attenuated by
PI3-kinase inhibitors ( LY294002 and wortmannin ), and an AKT inhibitor
Wang et al., J Cell Physiol 2011
:
Taken together, these results suggested that in astrocytes, activation of NF-?B by ET ( B ) -dependent c-Src,
PI3K/Akt , and p42/p44 MAPK signalings is
necessary for ET-1 induced
iNOS gene up-regulation
Liu et al., Eur J Pharmacol 2013
:
Furthermore, a
phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 significantly
suppressed LPS induced NF-?B p65 nuclear translocation,
iNOS expression, and NO production, which was also mimicked by pretreatment with DSC
Huang et al., Toxicol Appl Pharmacol 2013
(Inflammation) :
We also found that LTA induced
iNOS and COX-2 up-regulation were
attenuated by p38, JNK, and
PI3-kinase inhibitors