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EDN3 — NOS3
Text-mined interactions from Literome
Barton et al., J Am Soc Nephrol 2000
(Glomerulosclerosis, Focal Segmental...) :
Dysfunctional renal
nitric oxide synthase as a determinant of salt-sensitive hypertension : mechanisms of renal artery endothelial dysfunction and
role of
endothelin for vascular hypertrophy and Glomerulosclerosis
Ye et al., Hypertension 2003
:
We asked whether
endothelin might
play a role in the control of basal or osmotically regulated NPR-A or
eNOS gene expression in these cells ... Increased extracellular tonicity reduced endothelin mRNA accumulation in these cells ( approximately 15 % of control levels ) ; however, exogenous
endothelin failed to normalize osmotically increased NPR-A activity or expression, or osmotically
suppressed eNOS expression
Sudjarwo et al., Eur J Pharmacol 1992
:
These results suggest that
ET-3 acts on ETB receptors in the vascular endothelium to increase [Ca2+ ] i by releasing Ca2+ from storage sites and by opening non-L type Ca2+ channels,
activates nitric oxide synthase , releases nitric oxide and relaxes vascular smooth muscle
Ohlstein et al., J Neurosurg 1992
:
An l-arginine analog inhibitor of
nitric oxide synthase , L-NG-monomethyl arginine ( L-NMMA, 200 microM ), did not significantly
affect basal immunoreactive
endothelin levels
Novella et al., Eur J Cardiothorac Surg 2007
(Cardiovascular Diseases) :
No change in the AVP response was produced by endothelium removal, exposure to the NO precursor ( 3 x 10 ( -4 ) M L-arginine ),
inhibition of
nitric oxide ( NO ) synthase ( 3 x 10 ( -5 ) M L-NAME ) or soluble guanylate cyclase ( 3 x 10 ( -6 ) M 1H- [ 1,2,4 ] oxadiazol [ 4,3,-alpha ] quinoxalin-1-one ( ODQ ) ), removal of the superoxide anion ( 100 U/ml superoxide dismutase ( SOD ) plus 1200 U/ml catalase ) or hydroxyl radical ( 10 ( -4 ) M deferoxamine ), or specific alpha1 - ( 10 ( -6 ) M prazosin ) or
endothelin ( 10 ( -5 ) M bosentan ) receptor antagonism
Chandrasekar et al., Pediatr Res 2008
(Disease Models, Animal...) :
PPHN was associated with decreases in
eNOS and ET-B receptor and
increase in
prepro-endothelin mRNA levels
Lin et al., Eur J Endocrinol 1998
:
Role of
nitric oxide synthase in release of
endothelin from cultured human endometrial cells