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CRP — NOS3

Text-mined interactions from Literome

Venugopal et al., Circulation 2002 : We tested the effect of CRP on eNOS expression and bioactivity in cultured human aortic endothelial cells ( HAECs ) ... CRP causes a direct reduction in eNOS expression and bioactivity in HAECs, further supporting its role in atherogenesis
Schwartz et al., Circ Res 2007 : Thus, CRP downregulates eNOS and attenuates reendothelialization in vivo in mice, and this action of CRP on eNOS is mediated at the level of gene transcription
Procopio et al., Endocrinology 2009 : Leptin stimulated endothelial nitric-oxide synthase via an adenosine 5'-monophosphate activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein
Tanigaki et al., Circ Res 2009 : C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine based inhibition motif of FcgammaRIIB and SHIP-1 ... We first show in mice that CRP inhibits insulin induced eNOS phosphorylation, indicating that these processes are operative in vivo