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BCL10 — NFKB1

Pathways - manually collected, often from reviews:

• KEGG Tuberculosis: Complex of BCL10-CARD9-MALT1 → NFKB1/RELA (protein-protein, activation)

Text-mined interactions from Literome

Badrichani et al., J Clin Invest 1999 : In addition, Bcl-2 or Bcl-XL inhibits activation of NF-kappaB and thus upregulation of proinflammatory genes
Tamatani et al., J Biol Chem 1999 : Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons ... Expression of the mutant NFkappaB completely inhibited NFkappaB DNA binding activity and inhibited both TNF induced up-regulation of Bcl-2 and Bcl-x expression and neuroprotective effect
Koseki et al., J Biol Chem 1999 : Expression of CIPER induced NF-kappaB activation, which was inhibited by dominant negative NIK and a nonphosphorylable IkappaB-alpha mutant but not by dominant negative RIP
Zhang et al., Nat Genet 1999 (Lymphoma, B-Cell, Marginal Zone...) : Wild-type BCL10 activated NF-kappaB but induced apoptosis of MCF7 and 293 cells
Costanzo et al., J Biol Chem 1999 : Expression of c-E10 under the control of a doxycycline dependent transcriptional transactivator results in NF-kappaB activation, which is inhibited by dominant negative forms of TRAF2 and NIK kinase
Lee et al., Proc Natl Acad Sci U S A 1999 (Lymphoma, B-Cell) : NF-kappaB mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes
Chen et al., J Biol Chem 1999 : The present study investigated the involvement of the transcription factor NF-kappaB in the expression of an anti-apoptotic gene, bcl-x , using a murine macrophage cell line and peritoneal macrophages from both wild type ( p50 ( +/+ ) ) and NF-kappaB p50 gene knockout ( p50 ( -/- ) ) mice
Chen et al., Mol Cell Biol 2000 : The expression of bcl-x suppressed apoptosis in the presence or absence of NF-kappaB activity
Tamatani et al., J Neurochem 2000 : These findings suggest a pathway where NFkappaB activation induces overexpression of Bcl-2 and Bcl-x , which function to prevent apoptotic cell death following H/R treatments
Bertin et al., J Biol Chem 2000 : BCL10/CLAP is an activator of apoptosis and NF-kappaB signaling pathways and has been implicated in B cell lymphomas of mucosa associated lymphoid tissue ... Although its role in apoptosis remains to be determined, BCL10 likely activates NF-kappaB through the IKK complex in response to upstream stimuli ... Although its role in apoptosis remains to be determined, BCL10 likely activates NF-kappaB through the IKK complex in response to upstream stimuli
Bertin et al., J Biol Chem 2001 : When expressed in cells, CARD11 and CARD14 activate NF-kappaB and induce the phosphorylation of BCL10
Ravi et al., Nat Cell Biol 2001 : Inhibition of NF-kappaB by blocking activation of the IkappaB kinase complex reduces Bcl-x L expression and sensitizes tumour cells to TRAIL induced apoptosis
Qiu et al., J Neurosci Res 2001 (Hypoxia, Brain) : Differential NF-kappa B regulation of bcl-x gene expression in hippocampus and basal forebrain in response to hypoxia ... The transcription factor NF-kappa B regulates bcl-x gene expression ... In this study, we examined the role of NF-kappa B in the regulation of bcl-x in hypoxia induced cell death
Gaide et al., FEBS Lett 2001 (Lymphoma) : Bcl10 , a caspase recruitment domain ( CARD ) -containing protein identified from a breakpoint in mucosa associated lymphoid tissue ( MALT ) B lymphomas, is essential for antigen-receptor mediated nuclear factor kappaB (NF-kappaB) activation in lymphocytes ... Moreover, expression of Carma1 induces phosphorylation of Bcl10 and activation of the transcription factor NF-kappaB
McAllister-Lucas et al., J Biol Chem 2001 (Lymphoma, B-Cell, Marginal Zone) : Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10 mediated NF-kappaB induction ... Bimp1 mediated NF-kappaB activation requires Bcl10 and IkappaB kinases, indicating that Bimp1 acts upstream of these mediators
Glasgow et al., Neurochem Res 2001 (Anoxia) : Transcriptional regulation of the BCL-X gene by NF-kappaB is an element of hypoxic responses in the rat brain
Cao et al., J Tongji Med Univ 2001 : To explore the effect of NF-kappa B on bcl-x gene transcription in extended drug resistance leukemia cell line HL-60/E6, drug-resistant subline HL-60/E6 was derived by intermittently exposing HL-60 cells to 6 ng/ml epirubicin ... It was concluded that NF-kappa B was involved in regulating bcl-x transcription
Vega et al., Adv Anat Pathol 2001 (Lymphoma, B-Cell, Marginal Zone...) : Recent work suggests that API2-MALT1 and BCL-10-MALT1 may activate NF-kB and a common downstream signaling pathway
Kasof et al., Oncogene 2001 (Prostatic Neoplasms) : Analysis of several anti-apoptotic proteins revealed that Bcl-x ( L ) levels and serine 32 phosphorylation of IkappaB, the natural inhibitor of NF-kappaB , were similarly elevated in cells expressing high levels of DR6, suggesting that NF-kappaB regulated survival proteins may protect from DR6 induced apoptosis and that DR6 is a target of NF-kappaB regulation
Shou et al., J Neurochem 2002 : NF-kappaB mediated up-regulation of Bcl-X ( S ) and Bax contributes to cytochrome c release in cyanide induced apoptosis ... NF-kappaB , a redox-sensitive transcription factor activated after cyanide treatment, is responsible for the up-regulation of Bcl-X ( S ) and Bax ... It was concluded that NF-kappaB mediated up-regulation of Bcl-X ( S ) and Bax is involved in regulating cytochrome c release in cyanide induced apoptosis
Stehlik et al., J Biol Chem 2003 : In transfection experiments, the CARD6 protein suppressed NF-kappa B induction by Nod1 or Cardiak but did not interfere with NF-kappa B activation by the CARD containing adapter protein Bcl10 or the cytokine tumor necrosis factor-alpha, demonstrating specificity of CARD6 for Nod-1 and Cardiak dependent pathways
Yorke et al., Eur J Cancer 2003 (Adenocarcinoma...) : Receptor activator of NF-kappaB ( RANK ) activation induces several survival signals including nuclear factor kappaB (NF-kappaB) and activation and upregulation of Bcl-xL
Ruefli-Brasse et al., J Biol Chem 2004 : Furthermore, deficiency in Bcl10 dependent NF-kappaB activation could be rescued in Rip2-/- embryonic fibroblasts by exogenous wild-type Rip2 but not a kinase-dead mutant
Wang et al., Mol Cell Biol 2004 : Consistently, expression of a mutant CARMA1, CARMA1 ( DeltaCD ), that can not associate with Bcl10 failed to restore CD3/CD28 costimulation induced NF-kappaB activation in JPM50.6 cells, whereas expression of Bcl10-CARMA ( DeltaCD ) fusion protein effectively restored this NF-kappaB activation
Zhou et al., Nature 2004 (Lymphoma, B-Cell, Marginal Zone) : Bcl10 is essential for NF-kappaB activation by T- and B-cell receptors ... Bcl10 overexpression is sufficient to activate NF-kappaB , a process that requires the NF-kappaB essential modulator NEMO ( also known as IKK-gamma ), which is the regulatory subunit of the IkappaB kinase complex ... Notably, a mutant form of NEMO that can not be ubiquitinated inhibited Bcl10 induced NF-kappaB activation ... Paracaspase and a ubiquitin conjugating enzyme ( UBC13 ) were both required for Bcl10 induced NEMO ubiquitination and subsequent NF-kappaB activation ... Thus, the adaptor protein Bcl10 promotes activation of NF-kappaB transcription factors through paracaspase- and UBC13 dependent ubiquitination of NEMO
Scharschmidt et al., Mol Cell Biol 2004 : Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling
Stilo et al., J Biol Chem 2004 : Expression of the NEMO binding region of CARMA3 exerts a dominant negative effect on Bcl10 mediated activation of NFkappaB
Chen et al., Apoptosis 2004 (Colonic Neoplasms) : Bcl-2, and to the less extent, Bcl-xL , were able to increase the activity of NF-kappa B , which was a known anti-apoptotic molecule in human colon cancer cells
Hosokawa et al., Int J Hematol 2004 (Lymphoma, B-Cell, Marginal Zone) : Recent genetic and biochemical studies have indicated that BCL10 and MALT1 form a physical and functional complex and are both essential for nuclear factor kappaB (NF-kappaB) activation by antigen receptor stimulation in lymphocytes
Tran et al., J Biol Chem 2005 (Astrocytoma...) : In addition, Fn14 activation induced BCL-XL and BCL-W mRNA and protein levels, and this effect was dependent upon NFkappaB transcriptional activity ... Our results suggest that NFkappaB mediated up-regulation of BCL-XL and BCL-W expression in glioma cells increases cellular resistance to cytotoxic therapy induced apoptosis
Woo et al., FEBS Lett 2004 : Inhibition of Bcl10 mediated activation of NF-kappa B by BinCARD, a Bcl10 interacting CARD protein ... BinCARD potently suppressed NF-kappa B activation induced by Bcl10 and decreased the amounts of phosphorylated Bcl10 ... Mutations at the residue Leu17 or Leu65, which is highly conserved in CARD, abolished the inhibitory effects of BinCARD on both Bcl10 induced activation of NF-kappa B and phosphorylation of Bcl10 ... These results suggest that BinCARD interacts with Bcl10 to inhibit Bcl10 mediated activation of NF-kappa B and to suppress Bcl10 phosphorylation
Ye et al., J Pathol 2005 (Lymphoma, B-Cell, Marginal Zone...) : The oncogenic activity of the three chromosomal translocations is linked by the physiological role of BCL10 and MALT1 in antigen receptor mediated NFkappaB activation
Hosokawa et al., Apoptosis 2005 (Lymphoma, B-Cell, Marginal Zone...) : Recent biochemical and genetic studies have clearly shown that BCL10 and MALT1 form a physical and functional complex and are both required for NF-kappaB activation by antigen receptor stimulation in T and B lymphocytes
Tian et al., Blood 2005 (Lymphoma, B-Cell) : Induction of Bcl10 activity caused rapid activation of nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK), but not activation of extracellular signal regulated kinase ( ERK ) or p38 mitogen activated protein ( MAP ) kinases
Nakamura et al., Pathobiology 2005 : The dysregulated overexpression of BCL10 that results from a specific chromosomal translocation t ( 1 ; 14 ) ( p22 ; q32 ) in mucosa associated lymphoid tissue lymphoma has been shown to activate nuclear factor (NF)-kappaB , which may promote growth and survival in tumor cells ... The aim of this study was to determine the molecular mechanisms underlying NF-kappaB activation by BCL10 overexpression ... Furthermore, the BCL10 mediated NF-kappaB activation was efficiently inhibited by a Ca2+ chelating agent or a Ca2+ channel blocker ... These findings suggest that the filamentous pattern of overexpressed BCL10 at the perinuclear region adjacent to the endoplasmic reticulum is important for the BCL10 mediated NF-kappaB activation
Hu et al., J Clin Invest 2006 (Lymphoma, B-Cell, Marginal Zone...) : While both BCL10 and MALT1 are critically involved in antigen receptor mediated NF-kappaB activation, the role of cIAP2 is not clear ... Furthermore, BCL10 and cIAP2-MALT1 synergistically activate NF-kappaB ... Furthermore, BCL10 and cIAP2-MALT1 synergistically activate NF-kappaB
Tao et al., Mol Cell Biol 2006 : Up-regulation of proapoptotic protein Bcl-XS and neuronal apoptosis induced by serum deprivation are blocked by inhibition and/or down-regulation of NF-kappaB and by prevention of K+ loss
Nakagawa et al., Leukemia 2006 (Lymphoma, B-Cell, Marginal Zone) : Several lines of evidence indicated that both BCL10 and MALT1 are required for nuclear factor kappa B (NF-kappaB) activation by antigen receptor stimulation in lymphocytes, and API2-MALT1 can bypass this BCL10/MALT1 signaling pathway
Rivera et al., Trends Immunol 2006 : The CARMA1-Bcl10-Malt1 adaptor complex regulates NFkappaB activation by antigen receptors in lymphocytes
Hu et al., Cell cycle (Georgetown, Tex.) 2006 : Furthermore, cIAP2-MALT1 and Bcl10 synergistically activate NF-kappaB
Ishiguro et al., Mol Cell Biol 2006 : CARMA1 and Bcl10 functionally interact and control NF-kappaB signaling downstream of the T-cell receptor ( TCR )
Gross et al., Nature 2006 : Card9 couples to Bcl10 and regulates Bcl10-Malt1 mediated NF-kappaB activation induced by zymosan
Khanbolooki et al., Mol Cancer Ther 2006 (Pancreatic Neoplasms) : NF-kappaB inhibition resulted in down-regulation of BCL-XL and XIAP, and silencing either restored TRAIL sensitivity in TRAIL-resistant cells
Ishiguro et al., Mol Immunol 2007 : S138A mutation prolongs Bcl10 induced NF-kappaB activation, suggesting that Bcl10 phosphorylation is involved in attenuation of NF-kappaB activation
Klemm et al., Proc Natl Acad Sci U S A 2007 : Bcl10 and Malt1 control lysophosphatidic acid induced NF-kappaB activation and cytokine production ... By using murine embryonic fibroblasts from Bcl10- or Malt1-deficient mice as a genetic model, we report that Bcl10 and Malt1 are critically required for the degradation of IkappaB-alpha and the subsequent NF-kappaB induction in response to LPA stimulation
McAllister-Lucas et al., Proc Natl Acad Sci U S A 2007 (Inflammation) : CARMA3/Bcl10/MALT1 dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells
Wang et al., Proc Natl Acad Sci U S A 2007 : Bcl10 plays a critical role in NF-kappaB activation induced by G protein coupled receptors
Jost et al., J Immunol 2007 : Bcl10/Malt1 signaling is essential for TCR induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection
Deeb et al., J Pharmacol Exp Ther 2007 (Prostatic Neoplasms) : Because expression of antiapoptotic Bcl-2, Bcl-xL , and X-chromosome linked inhibitor of apoptosis protein ( XIAP ) is regulated by NF-kappaB , both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB
Kunnumakkara et al., Cancer Res 2007 (Neovascularization, Pathologic...) : In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ), NF-kappaB activation , and expression of NF-kappaB regulated gene products ( cyclin D1, c-myc, Bcl-2, Bcl-xL , cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only
Wegener et al., Science's STKE : signal transduction knowledge environment 2007 : CARD11 ( CARMA1 ), Bcl10 , and Malt1 are required for nuclear factor NF-kappaB activation in response to antigen recognition
Hara et al., Nat Immunol 2007 (Listeriosis) : The CARMA1-Bcl-10-MALT1 complex is critical for the activation of transcription factor NF-kappaB in lymphocytes but has an unclear function in myeloid cells ... The CARMA1-Bcl-10-MALT1 complex is critical for the activation of transcription factor NF-kappaB in lymphocytes but has an unclear function in myeloid cells
Zeng et al., Mol Cell Biol 2007 : Phosphorylation of Bcl10 negatively regulates T-cell receptor mediated NF-kappaB activation ... Bcl10 plays a critical role in antigen receptor mediated NF-kappaB activation and lymphocyte development and functions
Takase et al., Kidney Int 2008 (Chronic Disease...) : Inhibition of NF-kappaB dependent Bcl-xL expression by clusterin promotes albumin induced tubular cell apoptosis
Lee et al., Int J Cancer 2008 (Carcinoma, Squamous Cell...) : A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
Aimbire et al., Int Immunopharmacol 2008 (Inflammation) : LLLT and an inhibitor of NF-kappaB nuclear translocation ( BMS 205820 ) attenuated the mRNA levels of Bcl-xL and A1 mRNA in lung neutrophils obtained from mice subjected to LPS induced inflammation
Stilo et al., J Cell Sci 2008 : A20 is a negative regulator of BCL10- and CARMA3 mediated activation of NF-kappaB
Hara et al., J Immunol 2008 : Although the caspase recruitment domain (CARD)9-Bcl10 complex is essential for FcRgamma/DAP12 mediated NF-kappaB activation in myeloid cells, its involvement in NK cell receptor signaling is unknown
Travert et al., J Immunol 2008 (Lymphoma, Follicular) : Thus, the antiapoptotic signaling of CD40, which interferes with TRAIL induced apoptosis in FL B cells, involves NF-kappaB mediated induction of c-FLIP and Bcl-x ( L ) which can respectively interfere with caspase 8 activation or mitochondrial mediated apoptosis
Kuo et al., Blood 2008 (Lymphoma, B-Cell, Marginal Zone...) : In B-cell lymphoma Pfeiffer cells, BAFF activated NF-kappaB and AKT ; the activated NF-kappaB up-regulated BCL10 , and the activated AKT caused formation of BCL10/BCL3 complexes that translocated to the nucleus
Takeda et al., Int Immunol 2008 : In addition, we found that Bcl10 induced NF-kappaB activation through CD28 mediated stimulation could be blocked by the dominant negative form of PKC or CARMA1
Kingeter et al., J Immunol 2008 : Loss of protein kinase C theta, Bcl10 , or Malt1 selectively impairs proliferation and NF-kappa B activation in the CD4+ T cell subset
Ghosh-Choudhury et al., Breast Cancer Res Treat 2009 (Adenocarcinoma...) : NFkappaB DNA binding activity and NFkappaB dependent transcription of Bcl-2 and Bcl-XL genes were also prevented by DHA and EPA treatment ... Finally, we showed that PTEN expression significantly inhibited NFkappaB dependent transcription of Bcl-2 and Bcl-XL genes
Bhattacharyya et al., Inflamm Bowel Dis 2009 : DSS induced increases in phospho-IkappaBalpha, nuclear NFkappaB ( p65 ), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species ( ROS ) -induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10 , which are associated with the innate immune pathway of NFkappaB-IL-8 activation
Goodridge et al., J Immunol 2009 : A recent report identified a role for CARD9 in innate anti-fungal responses, demonstrating CARD9-Bcl10 mediated activation of NF-kappaB and proinflammatory cytokine induction in murine bone marrow derived DC stimulated via Dectin-1
Lomonaco et al., DNA Cell Biol 2009 (Xeroderma Pigmentosum) : Given the important function of NF-kappaB in regulating transcription of the bcl-x ( l ) gene and the Bcl-x ( L ) protein in preventing apoptosis, these results suggest that NER may protect cells against cisplatin induced apoptosis by activating NF-kappaB , which further induces transcription of the bcl-x ( l ) gene, resulting in an accumulation of Bcl-x ( L ) protein and activation of the cell survival pathway that leads to increased cell survival under cisplatin treatment
Banerjee et al., Cancer Res 2009 (Pancreatic Neoplasms) : Our data provide mechanistic evidence for the first time showing that DIM potentiates the killing of pancreatic cancer cells by down-regulation of constitutive as well as drug induced activation of NF-kappaB and its downstream genes ( Bcl-xL , XIAP, cIAP, and survivin )
Marasco et al., Biochem J 2009 : When tested in cell assays for its capacity to block NF-kappaB activation, this peptide represses activation of NF-kappaB mediated by BCL10 , CARMA3 and PMA/ionomycin stimulation
Borthakur et al., Inflamm Bowel Dis 2010 : Bcl10 was required for PAF induced I kappaB alpha phosphorylation, NF-kappaB activation, and IL-8 production in NCM460, a cell line derived from normal human colon, and Caco-2, a transformed human intestinal cell line
Chan et al., J Pathol 2010 (Lymphoma, Extranodal NK-T-Cell) : Interleukin-2 induces NF-kappaB activation through BCL10 and affects its subcellular localization in natural killer lymphoma cells
Van Beek et al., Cell reports 2012 (Carcinoma, Hepatocellular...) : Here, we demonstrate that the saturated FA, palmitate, requires Bcl10 for NF-kB activation in hepatocytes ... Surprisingly, while CARMA3 also participates in the palmitate response, MALT1 is completely dispensable, thereby revealing an apparent nonclassical role for Bcl10 in NF-kB signaling
Paul et al., Autophagy 2012 : Protecting BCL10 from autophagic degradation, either by pharmacological or genetic inhibition of autophagy, results in increased activation of NFKB1-RELA
Zhang et al., Mol Cell Biol 1994 (Leukemia, Lymphocytic, Chronic, B-Cell...) : In contrast to I kappa B alpha ( MAD3 ), BCL3 does not cause NF-kappa B p50 to be retained in the cytoplasm ; instead, in cotransfection assays, it alters the subnuclear localization of p50
Dixon et al., Brain Res 1997 (Ischemic Attack, Transient) : In this study, we show that NF-kB p50 and NF-kB p65 act in synergy to transactivate the bcl-x promoter in co-transfected 293 cells ... These results suggest that activation of NF-kB can lead to increased expression of bcl-x as manifested by the increase in the short form of bcl-x
Willis et al., Cell 1999 (Cell Transformation, Neoplastic...) : Bcl10 and E10 activated NF-kappaB but caused apoptosis of 293 cells ... Truncated Bcl10 activated NF-kappaB but did not induce apoptosis