◀ Back to IRF6

IRF6 — MMP9

Text-mined interactions from Literome

Jin et al., J Immunol 1999 : However, in all four cell lines, LPS induced MMP-9 or augmented its expression
Corbel et al., Pulm Pharmacol Ther 1999 (Inflammation...) : Nedocromil sodium ( 30 mg/kg, ip ) had no influence on the LPS induced MMP activities, on neutrophil recruitment, or on IL-10 level, but this drug elicited a significant inhibition of TNF- alpha level
Fenton et al., Osteoarthritis Cartilage 2000 (Horse Diseases...) : The addition of 25 mg/ml of glucosamine prevented the increase in nitric oxide production, proteoglycan release and MMP activity induced by LPS or rhIL-1
Lim et al., Am J Respir Crit Care Med 2000 (Pulmonary Emphysema) : Airway macrophages from smokers released greater amounts of MMP-9 and TIMP-1 at baseline and in response to IL-1beta and LPS than did those of nonsmokers ... Anti-IL-10 antibody had no effect on MMP-9 production induced by LPS
Rosenberg et al., Brain Res 2001 (Brain Ischemia...) : The hydroxymate-type, MMP inhibitor, BB-1101, blocked the activation of MMP-2 and MMP-9 by LPS in mixed glial cultures
Corbel et al., Eur J Pharmacol 2001 (Acute Disease...) : These findings demonstrate that the two drugs can inhibit the in vivo increase in MMP induced by LPS , batimastat with a direct inhibitor effect on MMP activity and pirfenidone as a consequence of its antiinflammatory effect
Kang et al., Am J Respir Crit Care Med 2001 (Respiratory Distress Syndrome, Adult) : Genistein also substantially reduced the LPS induced CINC production and MMP-9 activity and suppressed neutrophil recruitment ... In addition, NF-kappaB activation appears to be an important mechanism mediating LPS induced CINC production and MMP-9 activity and resulting neutrophil recruitment associated with acute lung inflammation and injury
Nelissen et al., J Leukoc Biol 2002 : To investigate whether a functional link exists between PECAM-1 activation and gelatinase B production, the regulatory role of PECAM-1, IFN-gamma, IFN-beta, LPS , and PMA on the production of gelatinase B ( MMP-9 ) was studied in vitro in normal human umbilical vein endothelial cells ( HUVECs ), human peripheral blood mononuclear cells ( PBMCs ), and in a human monocytic leukemia cell line
Corbel et al., J Pharmacol Exp Ther 2002 (Lung Diseases) : In the first model, the lipopolysaccharide (LPS) induced increase in neutrophils, MMP-9 activity, and tumor necrosis factor (TNF)-alpha and TGF-beta release in bronchoalveolar lavage (BAL) was significantly reduced by RP 73-401 pretreatment
Lee et al., Glia 2003 : The expression of MMP-9 but not MMP-2 was increased by LPS ... Inhibition of PKC activity blocked the LPS induced activation of Erk1/2 as well as MMP-9 expression ... The results from the present study suggest that induction of MMP-9 by LPS in rat primary astrocytes is mediated, at least in part, by the sequential activation of PKC and Erk1/2
Liu et al., Yao Xue Xue Bao 2003 (Arthritis, Rheumatoid) : LPS did not directly affect the expression of MMP-9 in FLS, but it was found to indirectly cause the increase of MMP-9 expression in FLS by stimulating U937 cell
Lalu et al., Mol Cell Biochem 2003 (Cardiomyopathies...) : Although MMP-9 activity was not detected in the ventricles, LPS resulted in an increase in perfusate 92 kDa MMP-9 activity
Liuzzi et al., Brain 2004 : The expression of MMP-9 in both astrocytes and microglia was induced by LPS treatment and was dose-dependently inhibited by AZT and IDV treatment in LPS stimulated astrocytes and microglia
Speidl et al., FASEB J 2004 (Arteriosclerosis...) : Catecholamines potentiate LPS induced expression of MMP-1 and MMP-9 in human monocytes and in the human monocytic cell line U937 : possible implications for peri-operative plaque instability
Smith et al., Br J Ophthalmol 2004 : IL-1alpha and LPS had no effect on MMP/TIMP production by cultured corneal epithelial cells and keratocytes
Fiebich et al., Scand J Rheumatol Suppl 2004 (Inflammation) : LPS induced IL-6 and PGE2 release was only slightly inhibited at high doses, whereas LPS induced release of IL-8 and matrix metalloprotease (MMP)-9 was not affected
Woo et al., J Immunol 2004 : We showed that p38 kinase was essential for this induction and observed that LPS induced MMP-9 expression was sensitive to rottlerin, a putative protein kinase Cdelta (PKCdelta) inhibitor ... Interestingly, LPS induced MMP-9 expression and p38 kinase phosphorylation were shown to be suppressed by the antioxidant N-acetylcysteine and the flavoenzyme inhibitor diphenyleneiodonium chloride, but not by pyrrolidine dithiocarbamate, an NF-kappaB inhibitor ... LPS induced MMP-9 expression and p38 kinase phosphorylation were also inhibited by rotenone, a specific inhibitor of mitochondrial complex I, supporting the role of mitochondrial ROS in LPS signaling to MMP-9
Lu et al., J Leukoc Biol 2005 : Here, we show that LPS stimulation of monocytes results in MMP-9 production through a phosphatidylinositol-3 kinase (PI-3K)/Akt/inhibitor of kappaB (IkappaB) kinase-alpha ( IKKalpha ) /nuclear factor (NF)-kappaB pathway ... LY294002 or wortmannin, inhibitors of PI-3K, suppressed LPS induced Akt activity and MMP-9 production
Nareika et al., Am J Physiol Endocrinol Metab 2005 : Sodium lactate increases LPS stimulated MMP and cytokine expression in U937 histiocytes by enhancing AP-1 and NF-kappaB transcriptional activities
Xue et al., J Pharmacol Exp Ther 2006 : Tipifarnib also inhibited LPS induced secretion of MMP-9 , IL-6, MCP-1, and IL-1beta in THP-1 cells
Robinson et al., Shock 2006 (Endotoxemia) : As LPS induced gastric injury is mediated in part by iNOS, and NO modulates MMP production in vitro, we hypothesized that NOS inhibition would similarly modulate LPS induced gastric MMP production ... Therefore, the purpose of these studies was to compare the effects of selective and nonselective NOS inhibition on LPS induced gastric MMP production
Liu et al., J Neurosci Res 2006 : Zymography and real-time PCR showed that lipopolysaccharide (LPS) dramatically increased latent MMP-9 gelatinolytic activity and MMP-9 mRNA expression ... By using the NO donor DETA NONOate, we observed a dose dependent inhibition of MMP-9 induction by LPS ... The MEK1/2 inhibitor U0126 completely inhibited LPS induced MMP-9 , which was partially inhibited by the p38 MAPK inhibitor SB203580 ... Knockdown of AUF-1 with siRNA partially reversed the inhibitory action of NO on LPS stimulated MMP-9 induction ... We conclude that NO does not activate MMP-9 in astrocyte cultures but reduces LPS induced MMP-9 expression via accelerating MMP-9 mRNA degradation, which is partially mediated by AUF-1
Liu et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2005 : [ Effects of vasoactive intestinal peptide on LPS induced MMP-9 expression by alveolar macrophages in rats ] ... To explore the role of vasoactive intestinal peptide (VIP) on LPS induced MMP-9 expression by alveolar macrophages ( AM ) in rats ... VIP ( 10 ( -9 ) to approximately 10 ( -6 ) mol/L ) down-regulated LPS induced MMP-9 activity and its expression ... VIP can decrease LPS induced MMP-9 activity and its expression, which may be related to protein kinase C and calmodulin pathway
Melamed et al., Int Immunol 2006 : LPS and phorbol 12-myristate 13-acetate suppressed MMP-9 secretion in transitional cells, whereas LPS and concanavalin A stimulated MMP-9 secretion in mature B cells
Li et al., Biol Reprod 2007 : The aim of this study was to assess the mediating role of PGs on lipopolysaccharide (LPS) induced MMP9 secretion in vitro
Gao et al., Inflamm Bowel Dis 2007 (Crohn Disease) : LPS stimulation of whole blood increased the MMP-9 levels in plasma significantly in CD patients and controls, but infliximab had no effect on the secretion
Rhee et al., J Biochem Mol Biol 2007 : Here, we show that the transcription of the MMP-9 gene is induced by lipopolysaccharide (LPS) stimulation in cells of a macrophage lineage ( RAW 264.7 cells ) ... In addition, the degradation of IkappaBalpha, and the presences of myeloid differentiation protein ( MyD88 ) and tumor necrosis factor receptor associated kinase 6 ( TRAF6 ) were found to be required for LPS activated MMP-9 expression ... Chromatin immunoprecipitation ( ChIP ) assays showed that functional interaction between NF-kappaB and the MMP-9 promoter element is necessary for LPS activated MMP-9 induction in RAW 264.7 cells ... In conclusion, our observations demonstrate that NF-kappaB contributes to LPS induced MMP-9 gene expression in a mouse macrophage cell line
Tsai et al., J Cell Biochem 2008 : We tested the hypothesis, and explored the underlining mechanisms that cilostazol, a phosphodiesterase 3 inhibitor with antiplatelet and antithrombotic properties, inhibits lipopolysaccharide (LPS) induced MCP-1 and MMP-9 expression ... In monocytic THP-1 cells, cilostazol and N6,O2'-dibutyryl-cAMP ( dioctanoyl-cAMP, a cAMP analog ) dose-dependently inhibited LPS induced MCP-1 protein expression and MMP-9 activation, but did not affect the tissue inhibitor of metalloproteinase-1 ... Cilostazol significantly inhibited LPS induced activation of p38, JNK, and nuclear factor-kappaB, and the respective inhibitors of p38 and JNK greatly reduced the level of LPS induced MCP-1 and MMP-9 , suggesting the involvement of the p38 and JNK pathways ... In conclusion, cilostazol administered with LPS in vivo reduced neointimal hyperplasia and macrophage infiltration in the balloon injured rabbit aorta ; in vitro, cilostazol inhibits LPS induced MCP-1 and MMP-9 expression
Shin et al., Arch Pharm Res 2007 (MAP Kinase Signaling System) : We reported previously that lipopolysaccharide (LPS) induced MMP-9 expression through ERK1/2 pathway in rat primary astrocytes ( Glia 41 : 15-24, 2003 ) ... Treatment with a specific p38 MAPK inhibitor SB203580, but not JNK inhibitor SP600125, increased the LPS stimulated MMP-9 expression in a concentration dependent manner ... Finally, direct injection of SB203580 into the lateral ventricle of rat brain increased the LPS induced MMP-9 activity in cerebral cortex
Liuzzi et al., Neurochem Res 2007 (Multiple Sclerosis) : The treatment with both omega-3 PUFA and fish oil dose-dependently inhibited the LPS induced production of MMP-9
Kidachi et al., Cell Biol Int 2007 (Cell Transformation, Neoplastic...) : Treatment of cells with IFN-gamma alone did not alter MMP-9 mRNA expression or pro-MMP-9 production, but LPS alone and IFN-gamma+LPS co-treatment enhanced them significantly
Nareika et al., J Endocrinol 2008 : We have demonstrated recently that high glucose augments lipopolysaccharide (LPS) stimulated matrix metalloproteinase ( MMP ) and cytokine expression by U937 mononuclear cells and human monocyte derived macrophages
Chaves-Pozo et al., Mol Immunol 2008 : Finally, although none of the stimuli used were able to induce the gelatinolytic activity of Mmp9-like in head-kidney acidophilic granulocytes, the expression of mmp9 , timp2a and timp2b were all up-regulated by LPS/VaDNA in these cells, while only mmp9 and timp2a expression increased upon stimulation with gelatin
Crocker et al., Glia 2008 : In contrast, microglia constitutively expressed high levels of MMP-12 and showed strong induction of MMP-9 and MMP-14 in response to LPS ... Gelatin zymography confirmed that LPS and TNF-alpha induced strong expression of MMP-9 in microglia but not astrocytes ... Using this system, we have shown that astrocytes and microglia express distinct sets of MMP genes and that microglia, not astrocytes, are the major source of MMP-9 in response to LPS or TNF-alpha
Lee et al., Neurochem Res 2008 : LPS stimulation increased MMP-9 and decreased tPA activity in rat primary astrocytes ... Co-treatment with a cAMP analog, dibutyryl-cAMP ( db-cAMP ), or the cAMP elevating beta-adrenergic agonist, isoproterenol, concentration-dependently inhibited LPS induced MMP-9 activity
Sundararaj et al., J Leukoc Biol 2008 : In this study, we reported that simvastatin, a 3-hydroxyl-3-methylglutaryl-CoA reductase inhibitor, effectively inhibited LPS stimulated MMP-1 as well as MMP-8 and MMP-9 expression by U937 mononuclear cells
Dawes et al., Am J Vet Res 2008 : Effects of lactoferrin on LPS induced gene expression of cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 were monitored by use of PCR assays
Cheng et al., Mol Cell Biochem 2009 : Evidences suggest that lipopolysaccharide (LPS) participates in the inflammatory response in the cardiovascular system ; however, it is unknown if LPS is sufficient to upregulate expressions and/or activity of uPA, tPA, MMP-2 , and MMP-9 in myocardial cells ... In this study, we treated H9c2 cardiomyoblasts with LPS to explore whether LPS upregulates uPA, tPA, MMP-2 , and MMP-9, and further to identify the precise molecular and cellular mechanisms behind this upregulatory responses ... Here, we show that LPS challenge increased the protein levels of uPA, MMP-2 and MMP-9, and induced the activity of MMP-2 and MMP-9 in H9c2 cardiomyoblasts ... Collectively, these results suggest that LPS upregulates the expression and/or activity of uPA, MMP-2 , and MMP-9 through ERK1/2 signaling pathway in H9c2 cardiomyoblasts
Park et al., J Neuroimmunol 2009 (Encephalitis...) : KRG and GTS inhibited LPS induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells
Mendes et al., Cell Signal 2009 : Microarray analyses of the effects of NF-kappaB or PI3K pathway inhibitors on the LPS induced gene expression profile in RAW264.7 cells : synergistic effects of rapamycin on LPS induced MMP9-overexpression ... We also performed real-time RT-PCR assays on mmp9 expression using rosiglitazone ( agonist of PPARgamma ), PD98059 ( inhibitor of Erk 1/2 ) and SB203580 ( inhibitor of p38 ( MAPK ) ), that were able to counteract the rapamycin mediated overexpression of mmp9 in response to LPS
Lee et al., Exp Mol Med 2009 (MAP Kinase Signaling System) : In addition to mouse serum, conditioned media of Raw 264.7 cells contained the inhibitory factor ( s ) larger than 10 kDa, which suppressed SP600125- or LPS induced MMP-9 expression
Wang et al., Arch Biochem Biophys 2009 : The study showed that LPS induced transcription and protein expression of both MMP-9 and MUC5AC in NCI-H292 cells and in primary human epithelial cells, and the increased MUC5AC level were associated with increased MMP-9 transcripts, protein and activity ... Doxycycline inhibited MMP-9 transcription, protein production and activity, while LPS induced increase of MMP-9 transcription was inhibited by EGFR inhibitor, p38 MAPK and JNK inhibitor
Binker et al., Biochem Biophys Res Commun 2009 (Pulmonary Disease, Chronic Obstructive) : In the present study we investigated the signaling pathway mediating LPS stimulated secretion and activation of MMP-9 , and the regulatory effects of this pathway on the production of MUC5AC in the human airway cells NCI-H292
Jackson et al., J Immunol 2009 (Hypersensitivity) : LPS also induced expression of matrix metalloprotease 9 (MMP9) and failed to induce CD23 cleaving activity in MMP9 ( -/- ) cells, thus implicating MMP9 in the LPS induced release of CD23 from the cell surface ... Finally, type 1 transitional B cells uniquely produce MMP9 in response to LPS , suggesting a mechanism wherein endotoxin induces T1 cell expression of MMP9, which mediates cleavage of CD23 on distinct, mature B cells
Kim et al., Immunol Cell Biol 2010 : In addition, NAC or apocynin attenuated LPS induced ROS production and MMP-9 expression
Lirussi et al., Br J Pharmacol 2010 (Chorioamnionitis) : LPS induced over-expression of MMP2 and MMP9 in normal human myometrium was paralleled by an overactivity of the proteins
Li et al., Mol Biol Rep 2011 : Transfection of HASMCs with TLR4 siRNA-1 resulted in down-regulation of LPS induced expression of MMP-9
Ho et al., J Interferon Cytokine Res 2010 : Modulation of FLI-1 expression using either RNA interference or forced expression identified a positive role for FLI-1 in contributing to LPS induced expression of MMP-1, MMP-3 , MMP-10, and interleukin-10 (IL-10)
Hyc et al., Int J Mol Med 2011 : LPS increased the mRNA levels of IL-6, IL-1ß, TGF-ß1, MMP1a, MMP1b, MMP3 , MMP9, MMP13, MMP14, TIMP1 and TIMP3 while the mRNA levels of MMP2, TIMP2 and TIMP4 were significantly decreased
Gorina et al., Glia 2011 : Interplay between these signals was evidenced by the increased induction of MMP-9 in Stat1-deficient cells challenged with LPS, suggesting that Stat1 negatively regulates the expression of MMP-9 induced by LPS
Liu et al., Zhongguo Ying Yong Sheng Li Xue Za Zhi 2007 : [ Effects of CGRP on LPS induced MMP-9 secretion by alveolar macrophages ] ... To explore the effects of calcitonin-gene related peptide (CGRP) on LPS induced MMP-9 secretion by alveolar macrophages ( AM ) in vitro ... ( Only secreting a small amount of MMP-9 with unstimulated AM, LPS stimulated MMP-9 production in a concentration dependent manner ( p < 0.01 )
Wong et al., Invest Ophthalmol Vis Sci 2011 (Corneal Ulcer) : TLR4 and MMP-9 expression was dose-dependently increased by LPS
Yang et al., Yao Xue Xue Bao 2010 (Asthma...) : The activities of MMP-9 induced by LPS , TNF-alpha and PMA in THP-1 cells were determined by gelatin zymography method
Mayer et al., Toxicological sciences : an official journal of the Society of Toxicology 2011 : After a 17-h exposure of microglia to M.aeruginosa LPS, the following concentration dependent responses were observed : 0.1-100 ng/ml M. aeruginosa LPS enhanced O2? generation, with limited inflammatory mediator generation ; 1000-10,000 ng/ml M. aeruginosa LPS caused thromboxane B2 ( TXB2 ), matrix metalloproteinase-9 (MMP-9) , and macrophage inflammatory protein-2 ( MIP-2/CXCL2 ) release, concurrent with maximal O2? generation ; 100,000 ng/mL M. aeruginosa LPS deactivated O2? production but maintained elevated levels of TXB2, MMP-9, tumor necrosis factor-a (TNF-a), interleukin 1-a (IL-1a), and interleukin-6 (IL-6), macrophage inflammatory protein 1a ( MIP-1a/CCL3 ), and MIP-2/CXCL2, with concomitant lactic dehydrogenase release
Zhao et al., PloS one 2011 (Breast Neoplasms...) : In addition, knockdown of MTDH diminishes Nuclear Factor-kappa B ( NF-?B ) activation by LPS and inhibited LPS induced IL-8 and MMP-9 production
Kraus et al., PloS one 2012 (Bacteroidaceae Infections...) : In cell cultures, LPS induced a significant up-regulation of interleukin (IL) 1ß, IL6, IL8, MMP1 and MMP3
Kuo et al., J Periodontal Res 2012 : In the presence of both CsA and LPS , the MMP activities inhibited by CsA could still be observed in the co-cultures ... In the individual cultures, in contrast, the CsA inhibited MMP activities, in the presence of LPS , were minimally detected ... This study demonstrated that, in co-cultures of human gingival fibroblasts and U937 macrophages, CsA could inhibit MMP activities in the presence of P. gingivalis LPS
Desai et al., Atherosclerosis 2012 (Atherosclerosis...) : TNF-a- or LPS mediated MMP-9 protein levels ( measured by an immunoassay ) and enzyme activity ( determined by zymography ) were inhibited by META060 in a dose dependent manner
McElroy et al., PloS one 2012 : LPS induction of COX-2 requires Src-family kinase signaling while LPS transactivation of EGFR requires matrix metalloprotease ( MMP ) activity
Marquis et al., BMC complementary and alternative medicine 2012 (Periodontal Diseases) : The effects of auraptene and lacinartin on LPS induced cytokine and MMP secretion by macrophages were determined by immunological assays
Ko et al., Arch Oral Biol 2012 : Myricetin suppresses LPS induced MMP expression in human gingival fibroblasts and inhibits osteoclastogenesis by downregulating NFATc1 in RANKL induced RAW 264.7 cells
Lee et al., Cell Physiol Biochem 2012 : Atorvastatin and simvastatin, but not pravastatin, up-regulate LPS induced MMP-9 expression in macrophages by regulating phosphorylation of ERK and CREB ... Pro-inflammatory cytokines and lipopolysaccharide (LPS) induce matrix metalloproteinase (MMP)-9 gene expression in macrophages, which has been linked to progress of various inflammatory diseases ... The aim of this study was to identify effects of various statins on LPS induced MMP-9 gene expression in macrophages and microglia ... Atorvastatin and simvastatin, but not pravastatin, up-regulated LPS induced MMP-9 expression in murine RAW 264.7 macrophages and BV2 microglia ... The up-regulation of LPS induced MMP-9 gene expression by the statins was dependent on extracellular calcium ions and mediated by enhancing phosphorylation of cAMP-responsive element binding protein ... Geranylgeranyl pyrophosphate, a precursor for cholesterol synthesis, could suppress up-regulation of LPS mediated MMP-9 gene expression by atorvastatin and simvastatin ... Atorvastatin and simvastatin mediated up-regulation of LPS induced MMP-9 gene expression in macrophages and microglia in vitro raises an important concern about use of the widely prescribed statins in certain inflammatory conditions that are mediated by LPS
Palma et al., Rheumatology (Oxford) 2012 (Arthritis, Rheumatoid) : Moreover, we checked the ability of 15-deoxy-d ( 12,14 ) -prostaglandin J ( 2 ) ( 15d-PGJ, a PPAR? agonist ), MTX and methylprednisolone ( MP ) to affect PPAR? expression and lipopolysaccharide (LPS) induced MMP-9 activity ... At therapeutic concentrations, MTX and MP increase in vitro PPAR? protein expression and inhibit LPS induced MMP-9 activity
Choi et al., Int Immunopharmacol 2012 : In this study, we investigated the effects of aesculin on LPS stimulated MMP-9 production and its regulatory mechanism by using murine macrophage RAW264.7 cells
Bougault et al., Arthritis Rheum 2012 (Disease Models, Animal...) : LPS , IL-1a, and TNFa dose-dependently increased MMP-3, MMP-9 , and MMP-13 activity in cultured chondrocytes and in NLRP3 ( -/- ) chondrocytes, and this effect was not changed by inhibiting caspase 1 or IL-1ß
Zhao et al., PloS one 2012 (Peritonitis) : Accordingly, LPS induced cytokine, nitric oxide and MMP-9 production as well as the phagocytosis of bacteria were all up-regulated by NCTD in a dose dependent manner in both RAW264.7 cells and bone marrow derived macrophages ( BMMs )
Oh et al., Evidence-based complementary and alternative medicine : eCAM 2012 : Consistent with the inhibitory effect on PGE ( 2 ), KIOM-MA suppresses the LPS induced migration of macrophages and gelatinase activity and the expression of matrix metalloprotease-9 (MMP-9) in a dose dependent manner
Li et al., PloS one 2013 : Lentiviral RNAi targeting of ADAM17 down-regulates LPS induced MMP9 expression in lung epithelial cells via inhibition of TNF-a/NF-?B signaling
Lin et al., Shock 2013 (Acute Lung Injury) : In addition, LPS increased pulmonary tissue wet-to-dry weight ratio and tumor necrosis factor a and interleukin 8 levels in plasma and bronchoalveolar lavage fluid enhanced the expression of E-selectin, intercellular adhesion molecule 1, myeloperoxidase, MMP-2 , and MMP-9, whereas it decreased the expression of AQP-1 and AQP-5 in pulmonary tissue, all of which were attenuated by SalB pretreatment
Lew et al., PloS one 2013 (Fibrosis) : LPS increased LV expression of collagen Ia1, collagen IIIa1, MMP2, MMP9 , TIMP1, periostin and IL-6 ( P < 0.05 moderate vs low dose LPS and vs control )
Iwata et al., PloS one 2013 (Intervertebral Disc Displacement...) : Further, lipopolysaccharide (LPS) induced expression of TNF-a, MMP3, MMP13 , VEGF, and PGES mRNA in the 3D cultures, creating a molecular milieu that mimics that of degenerated NP
Lee et al., International journal of molecular sciences 2013 : In addition, Rg5 inhibited the mRNA expressions of iNOS, TNF-a, IL-1b, COX-2 and MMP-9 induced by LPS
Lively et al., Journal of neuroinflammation 2013 (Wounds and Injuries) : IL4 increased MMP2 and cathepsins S and K ; whereas LPS increased MMP9, MMP12 , MMP14 ( MT1-MMP ), heparanase, and cathepsin L1
Park et al., BioMed research international 2013 : The level and activity of LPS induced MMP-9 were reduced in GSC treated RAW264.7 cells
Xie et al., J Immunol 1994 : Time course analyses revealed that LPS regulated the expression of MMP-9 and MMP-2 via discordant kinetics ... TGF-beta stimulated production of both matrix metalloproteinases but blocked the LPS mediated secretion of MMP-9 ... LPS stimulated MMP-9 production was suppressed by genistein and tyrphostin, two specific tyrosine kinase inhibitors, as well as H-7, a serine/threonine protein kinase inhibitor, but not by HA1004, a relatively selective inhibitor for PKA and PKG
Saarialho-Kere et al., J Biol Chem 1993 : LPS also stimulated collagenase transcription but did not affect transcription of 92-kDa gelatinase
Gottschall et al., J Neurosci Res 1995 : Addition of INF gamma inhibited the LPS stimulated activity of MMP-9
Panagakos et al., J Endod 1996 : Little information is currently known regarding the effects of cytokines and lipopolysaccharides (LPS's) on matrix metalloproteinase ( MMP ) production by pulp cells in vitro
Shankavaram et al., J Leukoc Biol 1998 : These results provide evidence that tyrosine phosphorylation of cPLA2 is one of the initial steps needed for the LPS induced MMP production in human monocytes
Zhang et al., J Immunol 1998 : The PGE2 independent induction of monocyte MMP-9 and TIMP-1 by these cytokines differed from stimulation of MMP-9 and TIMP-1 by LPS , which is in large part PG-dependent
Deb et al., J Neurosci Res 1999 (Brain Neoplasms...) : A beta, but not interleukin-1beta (IL-1beta) or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells, as well as increased the expression of the well-known activator of MMP-2, membrane-type ( MT ) -MMP