Gene interactions and pathways from curated databases and text-mining

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INSR — SIRPA

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: SIRPA → INSR (directlyIncreases, SIRPA Activity)
    Evidence: insulin receptor is a tyrosine kinase that catalyzes the phosphorylation of several intracellular substrates, including the insulin receptor substrate (IRS) proteins, GAB-1, Shc, APS, p60(DOK), SIRPS, and c-Cbl