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IL4 — THY1

Text-mined interactions from Literome

Warner et al., J Immunol 1991 : Pretreated B cells displayed unique phenotypic changes after treatment with anti-Ig, including a diminution of Thy-1 expression in response to LPS + IL-4 , as well as a reduction in membrane IgM and J11d expression ( i.e., they were IgMlo, IgDmed, and J11dlo, as recently reported for anergic B cells in transgenic mice )
Snapper et al., J Immunol 1990 : IL-4 induces Thy-1 expression and IgE secretion by LPS -- and T cell stimulated murine B cells in vitro
Snapper et al., Cell Immunol 1990 : IFN-gamma suppresses IL-4 induced Thy-1 expression by inhibiting the induction of steady-state levels of Thy-1-specific mRNA
Louie et al., Int Immunol 1995 : Positive and negative regulation of Thy-1 expression on B lymphocytes by IL-4 ... Expression of the Thy-1 membrane antigen is generally confined to thymocytes and T lymphocytes, but its expression on B lymphocytes can be induced by culture with the lymphokine IL-4 ... The present study was designed to determine whether IL-4 signaling induces Thy-1 expression on all B lymphocytes, or whether this induction is dependent upon IL-4 mediated activation ... IL-4 was required for Thy-1 expression in cells which were dependent upon IL-4 for continuous growth in culture but markedly decreased Thy-1 expression in cells which are growth inhibited by IL-4 ... In a mutant subclone of the latter cells in which IL-4 signaling does not cause growth inhibition, IL-4 did not affect Thy-1 expression ... The regulation of Thy-1 expression by IL-4 is manifest at the level of Thy-1 mRNA