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IL12RB1 — IL4
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL12-mediated signaling events:
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
→
IL4 (IL4)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
Text-mined interactions from Literome
Murphy et al., Curr Top Microbiol Immunol 1999
:
Capacitance would simply involve expression of
IL-12R beta 1 and beta 2 subunits,
regulated by TCR,
IL-4 and IFNs
Naume et al., Cytokine 1993
:
The increased IL-4R expression induced by IL-12 and the increased
IL-12R expression
induced by
IL-4 may explain the synergistic proliferative activity detected in response to IL-12 and IL-4
Wu et al., Eur J Immunol 1997
:
Anti-CD3 induced expression of
IL-12Rbeta1 and of low-affinity IL-12 binding sites was partially
inhibited by TGF-beta2, IL-10 and
IL-4 ; however, TGF-beta2 and IL-10 completely abolished anti-CD3 induced expression of high-affinity IL-12 binding sites