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IL2 — ITK

Text-mined interactions from Literome

Ragin et al., BMC immunology 2005 (MAP Kinase Signaling System) : The Tec family kinase ITK has been shown to be important for the production of IL-2 by T cells stimulated in vitro and may represent a good target for blocking the production of this cytokine in vivo ... These data show that ITK is required for IL-2 production induced by SEB in vivo, and may regulate signals leading IL-2 production, in part by regulating phosphorylation of c-jun
Das et al., Bioorg Med Chem Lett 2006 : Compound 2 is identified as a potent and selective Itk inhibitor which inhibits anti-TCR antibody induced IL-2 production in mice in vivo
Janis et al., Genomics 1994 : The protein-tyrosine kinase gene Itk is expressed preferentially in T lymphoid cells of the mouse and is induced by IL-2
Tanaka et al., Eur J Immunol 1997 : Itk , a T cell-specific tyrosine kinase, is required for CD2 mediated interleukin-2 promoter activation in the human T cell line Jurkat ... Interleukin-2 (IL-2) promoter activity stimulated by cross linking of CD2, TCR/CD3, and CD28 with antibodies was significantly reduced by transient expression of an Itk mutant lacking the kinase activity ... These results demonstrate that Itk plays a role in IL-2 production, indicating a critical involvement of Itk in the initial stage of T cell activation by mediating signals from the TCR/CD3 complex, CD2, and CD28