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CTLA4 — IL2

Text-mined interactions from Literome

Pioli et al., Eur J Immunol 1999 : The results show that CTLA-4 stimulation inhibits IL-2 production induced by CD3-CD28 co-stimulation
Brunner et al., J Immunol 1999 : CTLA-4 engagement by mAbs inhibits , while CD28 enhances, IL-2 production and proliferation upon T cell activation ... CTLA-4 ligation inhibited CD3/CD28 induced IL-2 mRNA accumulation by inhibiting IL-2 transcription, which appears to be mediated in part through decreasing NF-AT accumulation in the nuclei ... These results indicate that CTLA-4 signaling inhibits events early in T cell activation both at IL-2 transcription and at the level of IL-2 independent events of the cell cycle, and does not simply oppose CD28 mediated costimulation
Nakaseko et al., J Exp Med 1999 : Upon T cell activation by cross linking with anti-CD3 and anti-CD28 antibodies, CTLA-4 engagement inhibited both proliferation and interleukin 2 production in tyrosine mutants as well as in wild-type CTLA-4 transfectants ... Furthermore, the mutant CTLA-4 lacking most of the cytoplasmic region strongly suppressed interleukin 2 production as well
Riley et al., J Immunol 2001 : ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement
Blazevic et al., J Clin Immunol 2001 : Inhibition studies using the B7-binding fusion protein CTLA4Ig and antibodies against CD80 and CD86 demonstrate that CTLA4Ig and anti-CD86 inhibited influenza-specific T cell proliferation, interleukin (IL)-2 and interferon (IFN)-gamma production, and generation of influenza-specific CD8+ CTL
Trzonkowski et al., Mech Ageing Dev 2002 : Stimulation of lymphocytes in vitro with IL2 resulted in an increase of the CD8 ( high+ ) CD152 ( + ) cells in the elderly, while it had no effect on lymphocytes of the young group
Gatta et al., Immunology 2002 : Results show that CTLA-4 engagement inhibits interleukin-2 (IL-2) production, not only when induced by CD3/CD28 costimulation, but also when CD4+ T cells are costimulated by anti-CD3 and anti-LFA-1 monoclonal antibodies ( mAbs )
Hwang et al., J Immunol 2004 (Anemia, Hemolytic, Autoimmune...) : We have previously reported that IL-2 is necessary for optimal up-regulation of CTLA-4 , an inducible negative regulator of T cell activation
Cheng et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2005 (Asthma...) : Asthma-specific immunotherapy could alleviate lung inflammation, decrease eosinophil infiltration in BALF ( P < 0.01 ) and serum OVA-specific IgE, inhibit the production of IL-2 and IL-4 and the proliferation of splenic T cells to OVA ( P < 0.01 ), and up-regulate the expression of CTLA-4 on splenic T cells
Chen et al., J Biol Chem 2006 : Ectopic expression of Foxp3 in non-T ( reg ) leads to repression of the interleukin 2 (IL-2) and interferon gamma (IFNgamma) genes, gain of suppressor function, and induction of genes such as CD25, GITR, and CTLA-4 , but the mode by which Foxp3 enforces this program is unclear
Ndejembi et al., J Immunol 2006 : In vitro, CTLA4Ig substantially inhibits IL-2 , but not IFN-gamma production from heterogeneous memory CD4 T cells specific for influenza hemagglutinin or OVA in response to peptide challenge
Aronson et al., Am J Vet Res 2011 : Cyclosporine, dexamethasone, cyclosporine-dexamethasone combination, and CTLA4-Ig caused a significant decrease in IL-2 , IFN-?, and GM-CSF production
Freeman et al., J Exp Med 1993 : Murine B7-2 costimulates the proliferation and interleukin 2 production of CD4+ T cells and this costimulation can be inhibited by either CTLA4-Ig or GL1 mAb
Van Gool et al., J Exp Med 1994 : Interaction of CD28/CTLA-4 on T cells with B7 on antigen presenting cells constitutes an important costimulatory signal for T cells and is responsible for cyclosporin A-resistant interleukin 2 (IL-2) gene expression and potentially also for prevention of anergy induction after T cell receptor triggering
Krummel et al., J Exp Med 1995 : Cross linking of CTLA-4 together with the TCR and CD28 strongly inhibits proliferation and IL-2 secretion by T cells
Tan et al., J Exp Med 1993 : Accumulation of interleukin 2 (IL-2) and interferon gamma but not IL-4 mRNA was blocked by CTLA4Ig in T cells stimulated by alloantigen
Toyooka et al., Int Immunol 1996 : Moreover, IL-2R expression and proliferation induced by stimulation with bm12 APC was inhibited by CTLA-4-Ig , a soluble recombinant fusion protein capable of blocking the CD28 co-stimulatory signals not only stimulate IL-2 production but also induce IL-2R expression by an IL-2 independent mechanism
Krummel et al., J Exp Med 1996 : CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
Walunas et al., J Exp Med 1996 : Instead, CTLA-4 signaling blocks IL-2 production, IL-2 receptor expression, and cell cycle progression of activated T cells ... These results suggest that CTLA-4 signaling does not regulate cell survival or responsiveness to IL-2, but does inhibit CD28 dependent IL-2 production
Woodward et al., Transplantation 1996 (Second Messenger Systems) : Anti-CD2 mAb and CTLA4Ig also inhibited interleukin (IL)-2 , IL-4, and IL-2 receptor ( CD25 )
Saha et al., J Immunol 1996 (Shock, Septic) : This salutary CTLA4Ig effect correlated with markedly diminished TSST-1 induced serum levels of TNF-alpha and IFN-gamma, but TSST-1 triggered IL-2 release was not affected
Alegre et al., J Immunol 1996 : Expression of CTLA4 induced by anti-CD3 mAb was inhibited by anti-IL-2 plus anti-IL-2R mAbs ... We conclude that both CD28 and IL-2 play important roles in the up-regulation of CTLA4 expression
Chambers et al., Eur J Immunol 1996 : Most interestingly, CTLA-4 mediated inhibition of IL-2 secretion was not influenced by the presence of PMA
Maiuri et al., Gastroenterology 1998 (Celiac Disease) : CTLA-4Ig down-regulated the expression of CD25, intercellular adhesion molecule 1, interleukin 2 , and interferon gamma ( stained lamina propria mononuclear cells/mm2 ; P < 0.05 ) induced by gliadin challenge, caused apoptosis of gliadin-specific T cells ( apoptotic T cells/mm2 ; P < 0.05 ), and inhibited the production of antiendomysial antibody ( P < 0.01 )
Alegre et al., J Immunol 1998 : Cross linking of CTLA-4 during activation of peripheral T cells reduces IL-2 production and arrests T cells in G1 ... Inhibition of binding of CTLA-4 to its ligands using soluble anti-CTLA-4 mAb during stimulation with Ag increased the production not only of IL-2 by Th1 clones, but also that of IL-3 and IFN-gamma by Th1 clones and of IL-3, IL-4, IL-5, and IL-10 by Th2 clones
Gomes et al., J Infect Dis 1998 (Chronic Disease...) : CTLA-4 blockade completely restored activation induced interleukin-2 secretion and increased interferon-gamma production