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CD8B — IL2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Munakata et al., No To Shinkei 1999
(Multiple Sclerosis) :
PBM
IL-2 production and CD 4/8 ratio significantly decreased ( p < 0.05, p < 0.05 ), and the number of neutrocytes and CD 11
b+CD 8+ ( % ) significantly
increased immediately after LCP ( p < 0.05, p < 0.05 )
Tscharke et al., Arch Virol 1999
(Disease Models, Animal...) :
The determine which cytokines might be involved in the
CD8 ( + ) cell dependent
response to ganglionic HSV infection,
IL-2 , IL-4, IL-6, IL-10, and IFN-gamma mRNA levels were measured in infected ganglia from immunocompetent and anti-CD8 treated mice
Noël et al., Int Immunol 2001
:
The production of both IFN-gamma and
IL-2 following SEB stimulation was greatly
impaired in co-cultures containing CD4 ( + ) T cells, but not
CD8 ( + ) T cells, isolated from unresponsive animals
Nelson et al., Genomics 2001
:
Both flu antigen plus
IL-2 activated CD4 ( + ) and
CD8 ( + ) T lymphoblasts and cord blood derived dendritic cells responded to Ser and Ala MIP-3alpha/CCL20
Verschelde et al., Cell Death Differ 2003
:
Activation of CD4 ( + ) or
CD8 ( + ) T cells by antigenic peptides
induced an early but transient IL-2 independent expression of A1 and Bcl-xl mRNA and proteins, whereas expression of Bcl-2 was delayed and required
IL-2
Salkowitz et al., J Infect Dis 2004
:
Recombinant interleukin (IL)-2 or IL-15 could substitute for help provided by CD4 ( + ) T cells, whereas
CD8 ( + ) T cell expansion was
blocked by
anti-IL-2 but not anti-IL-15 antibody
Bosque et al., Eur J Immunol 2005
:
Additionally, the inhibition of
IL-2 dependent CD4 ( + ) or
CD8 ( + ) T cell blast growth upon CD3 or CD59 ligation was dependent, at least partially, on FasL and/or APO2L/TRAIL
Takahashi et al., Proc Natl Acad Sci U S A 1992
:
CD4 and
CD8 regulate
interleukin 2 responses of T cells
Donskov et al., Br J Cancer 2006
(Carcinoma, Renal Cell...) :
In contrast,
IL-2/HDC resulted in an unchanged number of circulating monocytes and intratumoral macrophages, and in addition, a significantly increased number of intratumoral CD56 ( + ) NK cells ( P=0.008 ) and
CD8 ( + ) T cells ( P=0.019 ) compared with baseline
Kosaka et al., Cancer Sci 2006
:
Moreover, ASGM1 ( + ) CD8 ( + ) T cells, but not ASGM1 ( - )
CD8 ( + ) T cells, produced high levels of interferon (IFN)-gamma in
response to IL-12 plus
IL-2
Chaput et al., Gut 2009
(Adenocarcinoma...) :
Finally,
interleukin 6 and TGF beta 1 synergistically
induced the generation of
CD8 ( + ) CD25 ( + ) Foxp3 ( + ) T cells ex vivo
Umeshappa et al., J Immunol 2009
(Melanoma, Experimental) :
Their stimulatory effect on CD8 ( + ) CTL responses and antitumor immunity is mediated by
IL-2 secretion, CD40L, and CD80 signaling and is specifically
targeted to
CD8 ( + ) T cells in vivo via acquired pMHC I
Du et al., Chin J Integr Med 2009
(Carcinoma, Non-Small-Cell Lung...) :
The level of CD3 ( + ), CD4 ( + ), the ratio of CD4 and CD8 ( + ), IgA, IgM, IgG and
IL-2 decreased in patients with NSCLC on day 1 after operation, and the level of
CD8 and TNF-alpha
increased compared to pre-operation
Takatsuka et al., Int Immunol 2009
(Leukemia-Lymphoma, Adult T-Cell) :
G14, an
IL-2 dependent HTLV-I negative CD4 ( + )
CD8 ( + ) T-cell line previously established from an HTLV-I infected rat, constantly proliferated and produced IFN-gamma
Molloy et al., J Virol 2010
(Disease Models, Animal...) :
Contrastingly,
IL-2 signaling through CD25 is absolutely
required for
CD8 ( + ) T cell mononucleosis
Bos et al., Cancer Res 2010
(Neoplasms, Experimental) :
Production of
interleukin-2 by tumor resident CD4 ( + ) T cells
enhanced CD8 ( + ) T-cell proliferation and upregulated expression of granzyme B
Bushkin et al., Cell Immunol 1990
:
Cross linking of
CD8 and HLA class I molecules with appropriate monoclonal antibodies ( mAb ) and goat anti-mouse Ig ( GaMIg ) antibody
resulted in a marked proliferation of resting human CD8 cells in the presence of
interleukin-2 (IL-2)
Ma et al., Scand J Immunol 2011
(Colonic Neoplasms) :
This study aims to investigate the
role of tumour derived Foxhead box P3 (Foxp3) ( +
) interleukin (IL)-17 ( + ) T cells on suppressing tumour-specific
CD8 ( + ) T cells
Chen et al., J Immunol 2012
(Tuberculosis, Pulmonary) :
IL-2 treatments early after Mycobacterium tuberculosis infection of macaques
induced simultaneous expansion of CD4 ( + ) CD25 ( + ) Foxp3 ( + ) Treg,
CD8 ( + ) CD25 ( + ) Foxp3 ( + ) T cells, and CD4 ( + ) T effector/CD8 ( + ) T effector/V?2Vd2 T effector populations producing anti-M
Sawamukai et al., Blood 2012
(Graft vs Host Disease) :
Cell-autonomous
role of TGFß and
IL-2 receptors in CD4+ and
CD8+ inducible regulatory T-cell generation during GVHD
Zhang et al., Acta Biochim Biophys Sin (Shanghai) 2012
(Tuberculosis) :
Compared with the wild type and other control groups, mice treated with the combined plant-made vaccines showed significantly higher levels of interferon-? and
interleukin-2 production in
response to all four proteins, and higher levels of antigen-specific CD4 ( + ) and
CD8 ( + ) T-cell responses and immunoglobulin ( Ig ) G and IgA titers
Shameli et al., Eur J Immunol 2013
(Diabetes Mellitus, Type 1) :
We show that decreased
IL-2 production
impairs the regulatory capacity of memory-like autoregulatory
CD8 ( + ) CD122 ( + ) T cells
Kotlán et al., Immunol Lett 1988
:
The different
effect of alpha and gamma interferons and
interleukin 2 on the expression of CD2, CD3, CD4 and
CD8 antigens in comparison to histocompatibility antigens of human lymphocytes
Sainis et al., J Immunol 1988
(Disease Models, Animal...) :
We also derived
IL-2 dependent
CD4+/CD8- as well as CD4-/CD8- T cell lines from nephritic SNF1 mice, that could simultaneously induce IdLNF1 positive and cationic anti-DNA antibodies of IgG class
Carrel et al., Eur J Immunol 1988
:
IL 2 production was
induced by mAb B66 in CD4+, but not
CD8+ , clones, whereas both types of clones responded to stimulation by the anti-CD3 mAb Leu-4
Höllsberg et al., Proc Natl Acad Sci U S A 1995
:
CD8 T-cell stimulation with the wild-type peptide antigen
led to activation of p56lck kinase activity,
interleukin 2 secretion, cytotoxicity, and clonal expansion ...
CD8 T-cell stimulation with the wild-type peptide antigen
led to activation of p56lck kinase activity,
interleukin 2 secretion, cytotoxicity, and clonal expansion
Yamada et al., Br J Haematol 1994
(Leukemia, T-Cell) :
Established
IL-2 dependent double negative ( CD4-
CD8- ) TCR alpha beta/CD3+ ATL cells : induction of CD4 expression
Ravichandran et al., J Exp Med 1994
:
In the double positive transfectants, CD4 and
CD8 associated with equal amounts of p56lck ( Lck ), and both molecules
enhanced interleukin 2 (IL-2) production equivalently when cross linked with suboptimal levels of anti-TCR antibody
Lim et al., Mol Cells 1998
:
However, stimulation of
CD8-Igbeta can
induce activation of CD69 surface expression and
IL-2 gene expression equivalent to the level by CD8-Igalpha and CD8-zeta without induction of the tyrosine phosphorylation of intracellular signaling molecules
Witte et al., Cell Immunol 1999
:
This enhancement of
IL-2 production is
independent of
CD8alpha or CD8beta cytoplasmic tails as demonstrated by analysis of cytoplasmic deletion mutants CD8alpha'beta, CD8alphabeta ', and CD8alpha'beta '