Zhao et al., Zhonghua Xin Xue Guan Bing Za Zhi 2006
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[ Effect of cardiotrophin-1 on cardiac transcription factor GATA4 expression in rat cardiomyocytes ] ... To investigate the effect of cardiotrophin-1 (CT-1) on the GATA4 expression and related signaling pathways ( JAK-STAT3, ERK1/2 and PI3-K ) in rat cardiomyocytes ... CT-1 increases the GATA4 mRNA expression and binding activity in rat cardiomyocytes via STAT3/ERK1/2 pathways and these effects are independent of PI3-K pathway
Xinyun et al., Int J Cardiol 2010
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CT-1 upregulates the expression of GATA4 , Nkx2-5, alpha-cardiac actin and beta-MHC mRNA, and rapidly promotes the differentiation and maturation of cardiomyocyte-like cells differentiated from BMMSCs induced with 5-azacytidine