Arnette et al., J Biol Chem 2003
:
Ca2+ signaling from intracellular stores is also essential for ERK1/2 activation, because thapsigargin blocks ERK1/2 activation by glucose or GLP-1 Ban et al., Endocrinology 2010
(Reperfusion Injury) :
Both GLP-1 ( 9-36 ) amide and exendin-4 increased levels of cAMP and phosphorylation of ERK1/2 and the phosphoinositide 3-kinase target protein kinase B/Akt