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EPHB2 — KRAS
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Yip-Schneider et al., Biochem Biophys Res Commun 2001
(Carcinoma...) :
We reported previously that the presence of oncogenic, activated
K-ras in human pancreatic carcinoma cell lines did not
result in constitutive activation of the extracellular signal regulated kinases (
ERK1 and ERK2 )
Khanzada et al., Oncogene 2006
(Carcinoma, Small Cell...) :
Downregulation of either H- or
K-Ras by RNA interference ( RNAi ) did not
impair Erk activation by growth factors, whereas an RNAi specific for N-Ras inhibited activation of Erk, PKB and SCLC cell growth
Van Meter et al., Blood 2007
(Myeloproliferative Disorders) :
Comparison of wild-type and Kras ( G12D ) c-kit ( + ) lin ( -/low ) cells shows that
K-Ras ( G12D ) expression causes hyperproliferation in vivo and
results in abnormal levels of phosphorylated STAT5,
ERK , and S6 under basal and stimulated conditions
Miller et al., Cancer Res 2009
(Cell Transformation, Neoplastic...) :
Oncogenic
Kras requires simultaneous PI3K signaling to induce
ERK activation and transform thyroid epithelial cells in vivo
Cassano et al., J Biol Chem 2010
(MAP Kinase Signaling System) :
Local
activation of
ERK1/2 by
Ki-Ras stimulates mitochondrial SOD, which reduces reactive oxygen species and produces H ( 2 ) O ( 2 )
Wang et al., FASEB J 2011
:
Dominant negative H-Ras or
K-Ras reduced accumulation of H-Ras and K-Ras in focal adhesions induced by IL-1 and also
blocked ERK activation and focal adhesion maturation
Wang et al., Cancer Discov 2011
(Prostatic Neoplasms) :
In NIH 3T3 cells,
UBE2L3-KRAS attenuates
MEK/ERK signaling, commonly engaged by oncogenic mutant KRAS, and instead signals via AKT and p38 mitogen activated protein kinase ( MAPK ) pathways
Majmudar et al., Bioorg Med Chem 2012
:
Cellular evaluation of 1b revealed that it alters the subcellular localization of
GFP-KRas , and also
inhibits both Ras activation and
Erk phosphorylation in Jurkat cells
Ravichandran et al., Mol Biol Cell 2013
(MAP Kinase Signaling System) :
These results demonstrate the versatility of the BCH domain of BPGAP1 in
regulating ERK signaling by involving
K-Ras and SmgGDS and support the unique role of BPGAP1 as a dual regulator for Ras and Rho signaling in cell morphogenesis and differentiation
Drew et al., Proteomics 2013
(Aberrant Crypt Foci...) :
ERK activation is responsible for observed hyperplasia found in these early lesions, but is not directly
dependent on
KRAS and/or BRAF mutation status
Itoh et al., Proc Natl Acad Sci U S A 1993
:
Both factors were necessary for
Ki-ras p21 dependent
activation of MAP
kinase/ERK2