Melchheier et al., Biochem Biophys Res Commun 2005
:
Loss of GJC was prevented by inhibition of ERK activation
Abdelmohsen et al., Biol Chem 2005
:
Doxorubicin induced loss of GJC was mediated by activation of extracellular signal regulated kinase ( ERK ) -1 and ERK-2, as demonstrated using inhibitors of ERK activation ... Thus, ERK dependent downregulation of GJC upon exposure to quinones may occur both by direct phosphorylation of Cx43 and in a phosphorylation independent manner