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Text-mined interactions from Literome

Woo et al., FASEB J 2010 : Novel role of C terminus of Hsc70 interacting protein ( CHIP ) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5 mediated degradation of inducible cAMP early repressor ... We identified ICER as a novel CHIP substrate and that the ERK5-CHIP complex plays an obligatory role in inhibition of ICER expression, cardiomyocyte apoptosis, and cardiac dysfunction
Le et al., Circ Res 2012 (Diabetes Mellitus, Experimental...) : We also identified ERK5-S496 as being directly phosphorylated by p90RSK and demonstrated that an ERK5-S496A mutant significantly impairs Angiotensin II-mediated inhibition of CHIP activity and subsequent increase in ICER levels