Friedberg et al., J Clin Endocrinol Metab 2003
:
CRH down-regulated 11 beta-HSD-1 activity with maximal effect at 10 ( -9 ) M ( 65 +/- 10 % of control ; P < 0.001 ) and caused a reduction in lipolysis ... Neither CRH nor ACTH affected 11 beta-HSD-1 mRNA expression
Fahlbusch et al., Reproductive biology and endocrinology : RB&E 2012
(Fetal Growth Retardation) :
We hypothesized that CRH might attenuate syncytialisation, induce leptin, and reduce 11beta-HSD2 expression in primary villous trophoblasts, which are known features of IUGR ... The induction of leptin and 11beta-HSD2 in the syncytiotrophoblast by CRH might promote fetal nutrient supply and placental corticosteroid metabolism in the phase before labour induction
Alderman et al., J Endocrinol 2012
:
Furthermore, inhibition of Hsd11b2 activity by 18ß-glycyrrhetinic acid resulted in elevated whole-body cortisol levels and preoptic area mRNA abundance of corticotropin releasing factor and mineralocorticoid receptor