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ANGPT2 — PIK3CA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Isenovic et al., Endocrinology 2004
(MAP Kinase Signaling System) :
To more specifically determine the
role of
PI3K in
Ang II-regulation of alpha ( 1 ) -and beta ( 1 ) -gene transcription, cells were cotransfected with a dominant negative p85 construct
El Mabrouk et al., Am J Physiol Heart Circ Physiol 2004
(Hypertension) :
Our data demonstrate that
PI3K and SAM68 are
involved in
ANG II signaling and that SAM68 is differentially regulated in VSMCs from SHR
Li et al., J Appl Physiol 2004
(Anoxia) :
ANG II-induced PN expression was
blocked by the AT(1)-receptor antagonist losartan and by inhibitors of
PI3K and MEK1/2
Isenovic et al., Int J Mol Med 2004
:
IGF-1 increased the association between IRS-1 and p85, and
Ang II as well as
PI3K inhibition decreased this IGF-1 effect
Liu et al., Zhonghua Zheng Xing Wai Ke Za Zhi 2010
(Cicatrix, Hypertrophic) :
Ang II increased Akt phosphorylation and
PI3K activity in cultured hypertrophic scar fibroblasts in a dose- and time dependent manner
Zhou et al., Vasc Med 2012
(Cardiovascular Diseases...) :
Angiotensin ( Ang ) II inhibits insulin mediated
PI3K pathway activation, thereby impairing endothelial NO production and Glut-4 translocation in insulin-sensitive tissues, which results in vascular and systemic insulin resistance, respectively