Gene interactions and pathways from curated databases and text-mining

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ANGPT2 — DUSP1

Text-mined interactions from Literome

Hannken et al., American journal of physiology. Renal physiology 2001 (Hypertrophy) : Although ANP and ANG II both stimulate generation of reactive oxygen species, ANP additionally induces expression of MKP-1 , leading to interference with ANG II-mediated MAP kinase phosphorylation
Pulver-Kaste et al., Am J Physiol Heart Circ Physiol 2006 (Calcium Signaling) : The physiological agonist ANG II also stimulated expression of Egr-1 and MKP-1
Fischer et al., Am J Physiol 1998 : In adult rat ventricular myocytes ( ARVM ) and cardiac microvascular endothelial cells ( CMEC ), we examined the role of ANG II signaling, via AT1 and AT2 receptors, on the activation of the extracellular signal regulated protein kinases ( ERKs ) and on the expression of the mitogen activated protein kinase ( MAPK ) phosphatase MKP-1 ... In contrast to the response in endothelial cells, however, ANG II activation of MKP-1 in ARVM was mediated by AT2-receptor activation
Maloney et al., Am J Physiol 1999 : ANG II-induced activations of Fyn, Raf-1, and ERK were augmented in cells pretreated with BAPTA-AM, but ANG II-induced expression of the dual-specificity phosphatase mitogen activated protein kinase phosphatase-1 was blocked by BAPTA-AM pretreatment