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ANGPT2 — DUSP1
Text-mined interactions from Literome
Hannken et al., American journal of physiology. Renal physiology 2001
(Hypertrophy) :
Although ANP and
ANG II both stimulate generation of reactive oxygen species, ANP additionally
induces expression of
MKP-1 , leading to interference with ANG II-mediated MAP kinase phosphorylation
Pulver-Kaste et al., Am J Physiol Heart Circ Physiol 2006
(Calcium Signaling) :
The physiological agonist
ANG II also
stimulated expression of Egr-1 and
MKP-1
Fischer et al., Am J Physiol 1998
:
In adult rat ventricular myocytes ( ARVM ) and cardiac microvascular endothelial cells ( CMEC ), we examined the
role of
ANG II signaling, via AT1 and AT2 receptors, on the activation of the extracellular signal regulated protein kinases ( ERKs ) and on the expression of the mitogen activated protein kinase ( MAPK ) phosphatase
MKP-1 ... In contrast to the response in endothelial cells, however,
ANG II activation of
MKP-1 in ARVM was mediated by AT2-receptor activation
Maloney et al., Am J Physiol 1999
:
ANG II-induced activations of Fyn, Raf-1, and ERK were augmented in cells pretreated with BAPTA-AM, but ANG II-induced expression of the
dual-specificity phosphatase mitogen activated protein kinase phosphatase-1 was
blocked by BAPTA-AM pretreatment